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Jeruk manis merupakan hibrida antara jeruk bali (''Citrus maxima'') dan mandarin (''Citrus reticulata'').<ref name=fullgenome>{{cite journal | doi = 10.1038/ng.2472 | volume=45 | title=The draft genome of sweet orange (Citrus sinensis) | journal=Nature Genetics | pages=59–66 | pmid=23179022 | date=Jan 2013 | last1 = Xu | first1 = Q | last2 = Chen | first2 = LL | last3 = Ruan | first3 = X | last4 = Chen | first4 = D | last5 = Zhu | first5 = A | last6 = Chen | first6 = C | last7 = Bertrand | first7 = D | last8 = Jiao | first8 = WB | last9 = Hao | first9 = BH | last10 = Lyon | first10 = MP | last11 = Chen | first11 = J | last12 = Gao | first12 = S | last13 = Xing | first13 = F | last14 = Lan | first14 = H | last15 = Chang | first15 = JW | last16 = Ge | first16 = X | last17 = Lei | first17 = Y | last18 = Hu | first18 = Q | last19 = Miao | first19 = Y | last20 = Wang | first20 = L | last21 = Xiao | first21 = S | last22 = Biswas | first22 = MK | last23 = Zeng | first23 = W | last24 = Guo | first24 = F | last25 = Cao | first25 = H | last26 = Yang | first26 = X | last27 = Xu | first27 = XW | last28 = Cheng | first28 = YJ | last29 = Xu | first29 = J | last30 = Liu | first30 = JH | last31 = Luo | first31 = OJ | last32 = Tang | first32 = Z | last33 = Guo | first33 = WW | last34 = Kuang | first34 = H | last35 = Zhang | first35 = HY | last36 = Roose | first36 = ML | last37 = Nagarajan | first37 = N | last38 = Deng | first38 = XX | last39 = Ruan | first39 = Y| issue=1 | doi-access = free }}</ref><ref name="AGLthesis">{{cite thesis |title=Organización de la diversidad genética de los cítricos |year=2013|author=Andrés García Lor| url=https://riunet.upv.es/bitstream/handle/10251/31518/Versión3.Tesis%20Andrés%20García-Lor.pdf |pages=79 }}</ref> Jeruk manis telah memiliki genom lengkap yang diurutkan.<ref name=fullgenome />
 
Jeruk manis berasal dari wilayah yang meliputi [[Tiongkok Selatan]], India Timur Laut dan [[Myanmar]].<ref>{{cite book | title = Fruits of Warm Climates | last=Morton | first=Julia F. | year=1987 | pages = 134–142 | url=https://hort.purdue.edu/newcrop/morton/orange.html}}</ref><ref>{{cite book | title = The Genus Citrus | last1 = Talon | first1 = Manuel | last2 = Caruso | first2 = Marco | last3 = Gmitter Jr. | first3 = Fred G. | year = 2020 | publisher = Woodhead Publishing | page = 17 | isbn = 9780128122174 | url = https://books.google.com/books?id=dslaDwAAQBAJ&pg=PA17}}</ref> Penyebutan jeruk manis paling awal ditemukan dalam literatur [[Tiongkok]] pada 314 SM.<ref name=fullgenome /> {{As of|1987}}, pohon jeruk ditemukan sebagai pohon buah yang paling banyak dibudidayakan di dunia.<ref name="morton">{{cite web|author=Morton, J|urldate=http://www.hort.purdue.edu/newcrop/morton/orange.html1987|title=Orange, ''Citrus sinensis''. In: Fruits of Warm Climates|dateurl=1987http://www.hort.purdue.edu/newcrop/morton/orange.html|publisher=NewCROP, New Crop Resource Online Program, Center for New Crops & Plant Products, Purdue University|pages=134–142}}</ref> Penyebutan jeruk manis paling awal ditemukan dalam literatur [[Tiongkok]] pada 314 SM.<ref name=fullgenome />
 
Pohon jeruk banyak ditanam di iklim tropis dan subtropis karena bisa menghasilkan buah yang manis. Buah jeruk dapat dimakan segar atau diolah untuk jus, sedangkan kulitnya bisa dimanfaatkan untuk bumbu karena harum.<ref name="ars-grin.gov">{{GRIN | Citrus sinensis | 10782 | access-date = 10 Desember 2017}}</ref> , Hingga tahun 2012, jeruk manis menyumbang sekitar 70% dari produksi ''citrus''.<ref name="citrusgenomedb.org">[https://web.archive.org/web/20120824011802/http://www.citrusgenomedb.org/organisms ''Organisms'']. Citrus Genome Database</ref>