Sinarizin: Perbedaan antara revisi
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'''Sinarizin''' adalah antihistamin dan penghambat saluran kalsium dari kelompok difenilmetilpiperazin.<ref name ="Terland">{{cite journal | vauthors = Terland O, Flatmark T | title = Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles | journal = Neuropharmacology | volume = 38 | issue = 6 | pages = 879–82 | date = June 1999 | pmid = 10465691 | doi = 10.1016/s0028-3908(98)00233-0 | s2cid = 40061724 }}</ref> Obat ini diresepkan untuk mual dan muntah akibat mabuk perjalanan<ref name ="Nicholson">{{cite journal | vauthors = Nicholson AN, Stone BM, Turner C, Mills SL | title = Central effects of cinnarizine: restricted use in aircrew | journal = Aviation, Space, and Environmental Medicine | volume = 73 | issue = 6 | pages = 570–4 | date = June 2002 | pmid = 12056673 }}</ref> atau sumber lain seperti kemoterapi,<ref>{{cite journal | vauthors = Wilder-Smith CH, Schimke J, Osterwalder B, Senn HJ | title = Cinnarizine for prevention of nausea and vomiting during platin chemotherapy | journal = Acta Oncologica | volume = 30 | issue = 6 | pages = 731–4 | year = 1991 | pmid = 1958394 | doi = 10.3109/02841869109092448 | doi-access = free }}</ref> vertigo,<ref name="Pianese">{{cite journal | vauthors = Pianese CP, Hidalgo LO, González RH, Madrid CE, Ponce JE, Ramírez AM, Morán LM, Arenas JE, Rubio AT, Uribe JO, Abiuso J, Hanuch E, Alegría J, Volpi C, Flaskamp R, Sanjuán AP, Gómez JM, Hernández J, Pedraza A, Quijano D, Martínez C, Castañeda JR, Guerra OJ, F GV | title = New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study | journal = Otology & Neurotology | volume = 23 | issue = 3 | pages = 357–63 | date = May 2002 | pmid = 11981396 | doi = 10.1097/00129492-200205000-00023 | s2cid = 23282116 }}</ref> atau penyakit Ménière.<ref name="Arab">{{cite journal | vauthors = Arab SF, Düwel P, Jüngling E, Westhofen M, Lückhoff A | title = Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 369 | issue = 6 | pages = 570–5 | date = June 2004 | pmid = 15138660 | doi = 10.1007/s00210-004-0936-3 | s2cid = 27410833 }}</ref> Cinnarizine adalah salah satu penyebab utama parkinsonisme akibat obat.<ref name ="Terland"/>
Cinnarizine pertama kali disintesis sebagai R1575 oleh Janssen Pharmaceutica pada tahun 1955. Nama nonproprietary berasal dari substituen cinnamyl pada salah satu atom nitrogen, digabungkan dengan akhiran generik "-rizine" untuk "vasodilator antihistamin/otak (atau perifer)".
==Kegunaan dalam Medis==
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