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Umeklidinium bromida: Perbedaan antara revisi

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Muhammad Anas Sidik (bicara | kontrib)
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←Membuat halaman berisi '{{Infobox drug | image = Umeclidinium bromide.svg | alt = | caption = | image2 = Umeclidinium bromide 3D.png | width2 = 175 <!-- Clinical data --> | tradename = Incruse Ellipta | Drugs.com = | MedlinePlus = | DailyMedID = Umeclidinium bromide | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_category = | routes_of_administration = Inhalation (DPI) | ATC_prefix = R03 | ATC_suffix = BB07 | ATC_supplemental = <br/>{{ATC|...'
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Muhammad Anas Sidik (bicara | kontrib)
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Baris 13:
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| routes_of_administration = InhalationInhalasi ([[DryInhaler powderserbuk inhaler|DPI]]kering)
| ATC_prefix = R03
| ATC_suffix = BB07
Baris 29:
| bioavailability =
| protein_bound = ~89%<ref name = "PI">{{cite web|title=Incruse Ellipta (umeclidinium inhalation powder) for Oral Inhalation Use. Full Prescribing Information|url=https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Incruse_Ellipta/pdf/INCRUSE-ELLIPTA-PI-PIL.PDF|publisher=GlaxoSmithKline, Research Triangle Park, NC 27709|access-date=22 February 2016|archive-date=10 July 2018|archive-url=https://web.archive.org/web/20180710050003/https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Incruse_Ellipta/pdf/INCRUSE-ELLIPTA-PI-PIL.PDF|url-status=dead}}</ref>
| metabolism = [[LiverHati]] ([[Sitokrom P450 2D6|CYP2D6]])
| elimination_half-life = 11 hoursjam
| excretion = [[FecesFeses]] (58%) anddan [[urineurin]] (22%)
 
<!-- Identifiers -->
Baris 44:
 
<!-- Chemical data -->
| IUPAC_name = DiphenylDifenil-[1-(2-phenylmethoxyethylfenilmetoksietil)-1-azoniabicycloazoniabisiklo[2.2.2]octanoktan-4-ylil]methanolmetanol bromidebromida
| C=29 | H=34 | Br=1 | N=1 | O=2
| StdInChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1
Baris 51:
}}
 
'''Umeklidinium bromida''' adalah antagonis muskarinik kerja panjang yang disetujui untuk pengobatan pemeliharaan [[penyakit paru obstruktif kronik]] (PPOK).[3]<ref name = "PI" /> Obat ini juga disetujui untuk indikasi ini dalam kombinasi dengan [[vilanterol]] (sebagai umeclidiniumumeklidinium bromidebromida/vilanterol)[4][5]<ref>{{cite journal | vauthors = Feldman GJ, Edin A | title = The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects | journal = Therapeutic Advances in Respiratory Disease | volume = 7 | issue = 6 | pages = 311–9 | date = December 2013 | pmid = 24004659 | doi = 10.1177/1753465813499789 | s2cid = 5744282 }}</ref><ref>{{Cite news | title = FDA Approves Umeclidinium and Vilanterol Combo for COPD | url = http://www.medscape.com/viewarticle/817964 | date = December 18, 2013 | publisher = Medscape}}</ref> dan juga sebagai kombinasi tiga terapi sebagai fluticasone[[flutikason]] furoatefuroat/umeclidiniumumeklidinium bromidebromida/vilanterol.[6<ref name="Trelegy Ellipta PI">{{cite web |title=TRELEGY ELLIPTA Package Insert |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209482s000lbl.pdf |publisher=GlaxoSmithKline |access-date=11 July 2020 |date=September 2017}}</ref> Obat ini tercantum dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia.[7]].<ref name="WHO22nd">{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }}</ref>
 
== Referensi ==
{{reflist}}
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