OnPada 21 DecemberDesember 2015, Zelarayán agreedmenyetujui tokontrak adengan contract withklub [[Liga MX]] side [[Tigres de la UANL|Tigres UANL]], signingdengan fornilai atransfer reportedyang dilaporkan sebesar 5.,5 millionjuta.<ref>{{cite web |date=21 Desember 2015 |title=Zelarayán se suma a los Tigres |trans-title=Zelarayán joins Tigres |url=http://www.tigres.com.mx/nota/zelarayan-se-suma-a-los-tigres/ |archive-url=https://web.archive.org/web/20160104182815/http://www.tigres.com.mx/nota/zelarayan-se-suma-a-los-tigres |archive-date=4 Januari 2016 |url-status=dead |access-date=30 Desember 2017 |publisher=Tigres UANL |language=es}}</ref><ref name=":3" /> HeIa debutedmemulai fordebutnya theuntuk clubklub thetersebut followingpada 10 JanuaryJanuari berikutnya, replacingmenggantikan [[Rafael Sóbis]] indalam akekalahan 1–01-0 loss atdi [[Deportivo Toluca F.C.|Toluca]]. Zelarayán mencetak gol pertamanya di luar negeri pada 5 Februari 2016, mencetak gol terakhir dalam kemenangan 3-1 di [[Chiapas F.C.|Chiapas]]. Pada 22 Januari 2017, ia mencetak dua gol dalam kemenangan kandang 4-2 melawan [[Club América|América]]. Pada 6 Maret 2019, setelah absen lama hampir lima bulan karena cedera, Lucas Zelarayán kembali ke lapangan bersama Tigres, masuk pada menit ke-83 untuk memastikan kemenangan agregat 3-0 melawan [[Houston Dynamo FC|Houston Dynamo]] di [[Piala Champions CONCACAF|Liga Champions CONCACAF]].<ref>{{Cite web |date=20 Desember 2018 |title=Lucas Zelarayán niega su salida de Tigres |url=https://www.futboltotal.com.mx/futbol-mexicano/lucas-zelarayan-niega-su-salida-de-tigres/2018/12 |access-date=15 Mei 2023 |website=Futbol Total: Un juego auténtico lleno de nobleza y emoción.}}</ref><ref>{{Cite web |title=Tigres UANL vs. Houston Dynamo FC - Football Match Summary - March 12, 2019 - ESPN |url=https://www.espn.com/soccer/match/_/gameId/538412 |access-date=15 Mei 2023 |website=ESPN.com}}</ref>
Zelarayán scored his first goal abroad on 5 February 2016, netting the last in a 3–1 win at [[Chiapas F.C.|Chiapas]]. On 22 January 2017, he scored a brace in a 4–2 home win against [[Club América|América]]. On 6 March 2019, After a long absence of almost five months due to injury, Lucas Zelarayán made his return to the pitch with Tigres, coming on in the 83rd minute to seal a 3–0 aggregate victory against the [[Houston Dynamo FC|Houston Dynamo]] in the [[2019 CONCACAF Champions League|CONCACAF Champions League.]]<ref>{{Cite web |date=20 Desember 2018 |title=Lucas Zelarayán niega su salida de Tigres |url=https://www.futboltotal.com.mx/futbol-mexicano/lucas-zelarayan-niega-su-salida-de-tigres/2018/12 |access-date=15 Mei 2023 |website=Futbol Total: Un juego auténtico lleno de nobleza y emoción.}}</ref><ref>{{Cite web |title=Tigres UANL vs. Houston Dynamo FC - Football Match Summary - March 12, 2019 - ESPN |url=https://www.espn.com/soccer/match/_/gameId/538412 |access-date=15 Mei 2023 |website=ESPN.com}}</ref>
