Bumetanid: Perbedaan antara revisi
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==Penelitian==
Di otak, bumetanid menghambat kotransporter kation-klorida NKCC1, dan dengan demikian menurunkan konsentrasi klorida internal di [[sel saraf|neuron]]. Pada gilirannya, perubahan konsentrasi ini membuat aksi [[Asam aminobutirat gamma|GABA]] lebih hiperpolarisasi, yang mungkin berguna untuk pengobatan [[sawan]] [[bayi|neonatal]], yang cukup sering tidak responsif terhadap pengobatan tradisional yang menargetkan GABA, seperti [[barbiturat]]. Oleh karena itu, bumetanid sedang dievaluasi sebagai obat antiepilepsi prospektif.<ref>{{cite journal | vauthors = Löscher W, Puskarjov M, Kaila K | title = Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments | journal = Neuropharmacology | volume = 69 | pages = 62–74 | date = June 2013 | pmid = 22705273 | doi = 10.1016/j.neuropharm.2012.05.045 | s2cid = 22267675 }}</ref>
Obat ini juga telah dipelajari sebagai pengobatan untuk [[autisme]].<ref>{{cite journal | vauthors = Sprengers JJ, van Andel DM, Zuithoff NP, Keijzer-Veen MG, Schulp AJ, Scheepers FE, Lilien MR, Oranje B, Bruining H | title = Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial | journal = Journal of the American Academy of Child and Adolescent Psychiatry | date = July 2020 | volume = 60 | issue = 7 | pages = 865–876 | pmid = 32730977 | doi = 10.1016/j.jaac.2020.07.888 | quote = Recent trials have indicated positive effects of bumetanide in autism spectrum disorder (ASD). | doi-access = free }}</ref><ref>{{cite journal | vauthors = Zhang L, Huang CC, Dai Y, Luo Q, Ji Y, Wang K, Deng S, Yu J, Xu M, Du X, Tang Y, Shen C, Feng J, Sahakian BJ, Lin CP, Li F | title = Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios | journal = Translational Psychiatry | volume = 10 | issue = 1 | pages = 9 | date = January 2020 | pmid = 32066666 | pmc = 7026137 | doi = 10.1038/s41398-020-0692-2 | doi-access = free }}</ref>
==Referensi==
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