Entakapon: Perbedaan antara revisi
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←Membuat halaman berisi '{{Drugbox | verifiedrevid = 477167001 | image = Entacapone.svg | alt = Skeletal formula | width = 200 | image2 = Entacapone molecule spacefill.png | alt2 = Space-filling model of entacapone <!--Clinical data--> | pronounce = {{IPAc-en|ˌ|ɛ|n|t|ə|k|ə|ˈ|p|oʊ|n}} or {{IPAc-en|ɛ|n|ˈ|t|æ|k|ə|p|oʊ|n}} | tradename = Comtan (bahan tunggal), Stalevo (multi bahan) | Drugs.com = {{drugs.com|monograph|entacapone}} | DailyMedID = Entacapone | MedlinePlus = a601236...' Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
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Baris 29:
<!--Pharmacokinetic data-->
| bioavailability = 35%
| protein_bound = 98% (
| metabolism = [[Hati]]
| elimination_half-life = 0,4–0,7 jam
Baris 65:
'''Entakapon''' adalah obat yang umum digunakan dalam kombinasi dengan obat lain untuk pengobatan [[penyakit Parkinson]]. Entakapon bersama dengan [[levodopa]] dan [[karbidopa]] memungkinkan levodopa memiliki efek yang lebih lama di otak dan mengurangi tanda dan gejala penyakit Parkinson dalam jangka waktu yang lebih lama daripada terapi levodopa dan karbidopa saja.<ref name=":02">{{Cite web|url = https://www.pharma.us.novartis.com/product/pi/pdf/comtan.pdf|title = Comtan Full Prescribing Information-Novartis|date = July 2014|access-date = 4 November 2015|website = Pharma.us.novartis.com|archive-date = 15 March 2016|archive-url = https://web.archive.org/web/20160315172434/http://www.pharma.us.novartis.com/product/pi/pdf/comtan.pdf|url-status = dead}}</ref>
Entakapon adalah [[penghambat enzim]] katekol-''O''-metiltransferase (COMT) yang selektif dan reversibel. Ketika dikonsumsi bersama dengan levodopa (<small>L</small>-DOPA) dan karbidopa, entakapon menghentikan COMT dari memecah levodopa, sehingga menyebabkan peningkatan keseluruhan levodopa yang tersisa di otak dan tubuh.<ref name=":02" /> Entakapon tidak masuk ke dalam otak dan karenanya tidak menghambat COMT di sana.<ref name="Habet2022">{{cite journal | vauthors = Habet S | title = Clinical Pharmacology of Entacapone (Comtan) From the FDA Reviewer | journal = Int J Neuropsychopharmacol | volume = 25 | issue = 7 | pages = 567–575 | date = August 2022 | pmid = 35302623 | pmc = 9352175 | doi = 10.1093/ijnp/pyac021 | url = | quote = Entacapone is a potent and specific peripheral catechol-O-methyltransferase inhibitor. [...] Entacapone has no antiparkinsonian activity as a sole agent. Therefore, it must be given as an adjunct to LD and a peripherally acting DDC inhibitor, such as carbidopa. Entacapone acts peripherally and does not penetrate the blood-brain barrier (BBB). [...] It is poorly lipophilic and does not penetrate the BBB to any significant extent. Its clinical effects are thus due to peripheral COMT inhibition only (Nutt, 1998; Fahn et al, 2004). [...] Entacapone is poorly lipophilic. Therefore, its clinical effects are due to peripheral COMT inhibition alone. [...] Entacapone is a potent, specific, and reversible COMT inhibitor. The drug has been shown to act peripherally, but not centrally, when given at clinically effective doses.}}</ref>
[[karbidopa/levodopa/entakapon]] (Stalevo), obat kombinasi yang dikembangkan oleh Orion Pharma dan dipasarkan oleh [[Novartis]], adalah formulasi tablet tunggal yang mengandung levodopa, karbidopa, dan entakapon.<ref>{{cite web | title=Stalevo- carbidopa, levodopa, and entacapone tablet, film coated | website=DailyMed | date=7 January 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5edfc3e7-f80d-47ee-897a-c02ff4eb3e74 | access-date=14 March 2020}}</ref>
==Kegunaan dalam medis==
==Kontraindikasi==
==Efek samping==
==Interaksi==
==Farmakologi==
==Penelitian==
== Referensi ==
{{Reflist}}
[[Category:Antiparkinsonian agents]]
[[Kategori:Karboksamida]]
[[Kategori:Katekol]]
[[Category:Catechol-O-methyltransferase inhibitors]]
[[Kategori:Obat yang dikembangkan oleh Novartis]]
[[Kategori:Nitrila]]
[[Kategori:Turunan nitrofenol]]
[[Category:Peripherally selective drugs]]
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