Hidralazin: Perbedaan antara revisi
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Hidralazin ditemukan saat para ilmuwan di Ciba sedang mencari pengobatan untuk [[malaria]].<ref name=Wermuth>{{cite book | vauthors = Wermuth CG | author-link = Camille Georges Wermuth|title=The Practice of Medicinal Chemistry|publisher=Academic Press|isbn=9780080568775|page=12|url=https://books.google.com/books?id=Qmt1_DQkCpEC&pg=PA12|language=en|url-status=live|archive-url=https://web.archive.org/web/20170226131556/https://books.google.com/books?id=Qmt1_DQkCpEC&pg=PA12|archive-date=26 February 2017|date=2 May 2011}}</ref> Obat ini dipatenkan pada tahun 1949.<ref>{{cite book|title=Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques|date=2013|publisher=Birkhäuser|isbn=9783034870948|page=206|url=https://books.google.com/books?id=i8LzBwAAQBAJ&pg=PA206|language=en|url-status=live|archive-url=https://web.archive.org/web/20161220130333/https://books.google.ca/books?id=i8LzBwAAQBAJ&pg=PA206|archive-date=20 December 2016}}</ref> Obat ini masuk dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia]].<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref>
==Sejarah==
Aktivitas [[antihipertensi]] hidralazin ditemukan oleh para ilmuwan di Ciba, yang mencoba menemukan obat untuk mengobati malaria; awalnya disebut C-5968 dan 1-hidrazinoftalazina; Aplikasi paten Ciba diajukan pada tahun 1945 dan dikeluarkan pada tahun 1949,<ref>{{cite web|title=Hydralazine|url=https://www.drugbank.ca/drugs/DB01275|publisher=Drugbank|access-date=4 March 2017|url-status=live|archive-url=https://web.archive.org/web/20170304114322/https://www.drugbank.ca/drugs/DB01275|archive-date=4 March 2017}}</ref><ref>{{cite web|title=hydralazine|url=https://pubchem.ncbi.nlm.nih.gov/compound/hydralazine#section=Physical-Description|publisher=PubChem|access-date=4 March 2017|language=en|url-status=live|archive-url=https://web.archive.org/web/20170304115216/https://pubchem.ncbi.nlm.nih.gov/compound/hydralazine#section=Physical-Description|archive-date=4 March 2017}}</ref><ref>[https://docs.google.com/viewer?url=patentimages.storage.googleapis.com/pdfs/US2484029.pdf US2484029]; see Example 1</ref> dan publikasi ilmiah pertama tentang aktivitas penurun tekanan darahnya muncul pada tahun 1950.<ref name=Wermuth/><ref name=Schroeder/><ref>{{cite journal | vauthors = Reubi FC | title = Renal hyperemia induced in man by a new phthalazine derivative | journal = Proceedings of the Society for Experimental Biology and Medicine | volume = 73 | issue = 1 | pages = 102–103 | date = January 1950 | pmid = 15402536 | doi = 10.3181/00379727-73-17591 | s2cid = 32603042 }}</ref> Obat ini disetujui oleh FDA pada tahun 1953.<ref>{{cite web|title=New Drug Application (NDA) 008303 Company: NOVARTIS Drug Name(s): Apresoline|url=http://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=008303|publisher=FDA|access-date=26 February 2017|url-status=live|archive-url=https://web.archive.org/web/20170226135437/http://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=008303|archive-date=26 February 2017}}</ref>
Obat ini merupakan salah satu obat antihipertensi pertama yang dapat diminum.<ref name=Cochrane2011rev/>
==Kegunaan dalam medis==
==Efek samping==
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