Isokonazol: Perbedaan antara revisi
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←Membuat halaman berisi '{{Infobox drug |IUPAC_name = (''RS'')-1-[2-[(2,6-Diklorobenzil)oksi]-2-(2,4-diklorofenil)etil]-1''H''-imidazola |image=Isoconazole.svg <!--Clinical data--> |tradename = |Drugs.com = {{drugs.com|international|isoconazole}} |pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |pregnancy_category = |legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |leg...' Tag: Suntingan perangkat seluler Suntingan peramban seluler Suntingan seluler lanjutan |
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'''Isokonazol''' adalah obat antijamur azola dan dapat menghambat bakteri gram positif.<ref name=Veraldi2013>{{cite journal | vauthors = Veraldi S | title = Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids | journal = Mycoses | volume = 56 | issue = Suppl 1 | pages = 3–15 | date = May 2013 | pmid = 23574019 | doi = 10.1111/myc.12054 | s2cid = 1881151 }}</ref><ref>{{cite book |title=[[The Merck Index]] |chapter=Isoconazole |edition=12th |page=5176 | isbn = 0-911910-12-3 | veditors = Budavari S | date = 1996 | vauthors = Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J }}</ref> Untuk infeksi kaki dan vagina, isokonazol memiliki efektivitas yang sama dengan [[klotrimazol]].<ref name=Oyeka1992>{{cite journal | vauthors = Oyeka CA, Gugnani HC | title = Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes | journal = Mycoses | volume = 35 | issue = 11–12 | pages = 357–361 | year = 1992 | pmid = 1302811 | doi = 10.1111/j.1439-0507.1992.tb00894.x | s2cid = 6764090 }}</ref><ref name=Cohen1984>{{cite journal | vauthors = Cohen L | title = Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole | journal = The British Journal of Venereal Diseases | volume = 60 | issue = 1 | pages = 42–44 | date = February 1984 | pmid = 6365236 | pmc = 1046268 | doi = 10.1136/sti.60.1.42 }}</ref> Isokonazol nitrat dapat digunakan dalam kombinasi dengan [[kortikosteroid]] [[diflukortolon]] untuk meningkatkan [[bioavailabilitas]]nya.<ref name=Veraldi2013/> Obat ini dipatenkan pada tahun 1968 dan disetujui untuk penggunaan medis pada tahun 1979.<ref name=Fischer2006>{{cite book | vauthors = Fischer J, Ganellin CR |author-link2=C. Robin Ganellin |date=2006 |title=Analogue-based Drug Discovery |language=en |publisher=John Wiley & Sons |isbn=9783527607495 |page=502 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA502}}</ref>
== Referensi ==
{{Reflist|2}}
[[Kategori:Penghambat 21-hidroksilase]]
[[Kategori:Penghambat aromatase]]
[[Kategori:Kloroarena]]
[[Kategori:Penghambat CYP17A1]]
[[Kategori:Eter feniletanolamina]]
[[Kategori:Antijamur imidazola]]
[[Kategori:Penghambat CYP51A1]]
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