Karbidopa: Perbedaan antara revisi
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==Farmakologi==
==Sintesis==
[[File:Carbidopa synthesis.svg|thumb|center|999px|Sintesis karbidopa:<ref>{{cite journal | vauthors = Sletzinger M, Chemerda JM, Bollinger FW | title = Potent Decarboxylase Inhibitors. Analogs of Methyldopa | journal = Journal of Medicinal Chemistry | volume = 6 | issue = 2 | pages = 101–103 | date = March 1963 | pmid = 14188777 | doi = 10.1021/jm00338a003 }}</ref><ref>{{Cite journal|doi=10.1021/jo00813a023|title=Synthesis of D- and L-α-(3,4-dihydroxybenzyl)-α-hydrazinopropionic acid via resolution|journal=The Journal of Organic Chemistry|volume=36|issue=14|pages=1946–1948|year=1971| vauthors = Karady S, Ly MG, Pines SH, Sletzinger M }}</ref><ref>{{Cite journal|doi=10.1021/jo00813a024|title=Synthesis of L-α-(3,4-dihydroxybenzyl)-α-hydrazinopropionic acid from optically active precursors by N-homologization|journal=The Journal of Organic Chemistry|volume=36|issue=14|pages=1949–1951|year=1971| vauthors = Karady S, Ly MG, Pines SH, Sletzinger M }}</ref>
;<ref>{{Cite patent|country=GB|number=940596|pubdate=1963-10-30|title=α-hydrazino acids|assign=[[Merck & Co. Inc.]]|inventor = Chemerda JM, Sletzinger M, Bollinger FW }}</ref> Chemerda ''et al''., {{US patent|3462536}} (kepada [[Merck & Co.]]). L-form.<ref>{{Cite patent|country=DE|number=2062285|pubdate=1971-07-01|title=L-α-Hydrazino-β-phenylpropionsäure-Verbindungen enthaltendes Arzneimittel [L-alpha-hydrazino-beta-phenylpropionic acid compounds, decarboxylase inhibitors]|assign=[[Merck & Co. Inc.]]| inventor = Karady S, Pines SH, Ly MG, Sletzinger M, Allegretti JE, Wildman Jr AS }}</ref><ref>{{Cite patent|country=DE|number=2062332|pubdate=1971-07-15|title=L-α-Hydrazino-β-phenylpropionsäure-Verbindungen und Verfahren zu deren Herstellung[L-alpha-hydrazino-beta-phenylpropionic acid compounds and processes for their preparation]|assign=[[Merck & Co. Inc.]]| inventor = Karady S, Pines SH, Ly MG, Sletzinger M, Allegretti JE, Wildman Jr AS }}</ref>]]
Sintesis diawali dengan [[Sintesis asam amino Strecker|reaksi Strecker]] yang dimodifikasi menggunakan [[hidrazina]] dan [[kalium sianida]] pada arilaseton ('''1''') untuk menghasilkan '''2'''. Zat ini kemudian dihidrolisis dengan HCl dingin untuk menghasilkan karboksamida '''3'''. Hidrolisis yang lebih kuat dengan 48% HBr memecah ikatan amida dan gugus aril eter untuk menghasilkan karbidopa ('''4''').
==Referensi==
{{Reflist}}
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