Menambahkan liotironin ke [[antidepresan trisiklik]] tampaknya bermanfaat, terutama pada wanita.[7]<ref>{{cite journal | vauthors = Altshuler LL, Bauer M, Frye MA, Gitlin MJ, Mintz J, Szuba MP, Leight KL, Whybrow PC | display-authors = 6 | title = Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature | journal = The American Journal of Psychiatry | volume = 158 | issue = 10 | pages = 1617–22 | date = October 2001 | pmid = 11578993 | doi = 10.1176/appi.ajp.158.10.1617 }}</ref> Algoritma yang dikembangkan dari uji coba STAR*D merekomendasikan liotironin sebagai pilihan ketika orang telah gagal dengan dua pengobatan [[antidepresan]].[8]<ref>{{cite journal | vauthors = Gaynes BN, Rush AJ, Trivedi MH, Wisniewski SR, Spencer D, Fava M | title = The STAR*D study: treating depression in the real world | journal = Cleveland Clinic Journal of Medicine | volume = 75 | issue = 1 | pages = 57–66 | date = January 2008 | pmid = 18236731 | doi = 10.3949/ccjm.75.1.57 | doi-broken-date = 12 November 2024 }}</ref>
