Pada 14 Juli 2024, klub [[Liga Utama Inggris]], [[Manchester United F.C.|Manchester United]], mengumumkan penandatanganan Zirkzee dengan kontrak lima tahun dengan biaya sebesar £36,5 juta.[29]<ref>{{cite news |title=Joshua Zirkzee: Man Utd complete £36.5m signing of Netherlands striker from Bologna |url=https://www.skysports.com/football/news/11095/13174655/joshua-zirkzee-man-utd-complete-gbp36-5m-signing-of-netherlands-striker-from-bologna |date=15 July 2024 |access-date=4 November 2024 |publisher=Sky Sports}}</ref> Ia melakukan debutnya sebagai pemain pengganti dalam pertandingan pembukaan musim melawan [[Fulham F.C.|Fulham]] pada 16 Agustus, di mana ia mencetak satu-satunya gol dalam pertandingan tersebut.[30][31]<ref>{{Cite web |last=Dawson |first=Rob |title=Joshua Zirkzee hails 'perfect' debut with Man United winner |url=https://www.msn.com/en-us/sports/other/joshua-zirkzee-hails-perfect-debut-with-man-united-winner/ar-AA1oW9IQ?ocid=BingNewsSerp |access-date=16 August 2024 |website=www.msn.com}}</ref><ref>{{cite web |last=Stone |first=Simon |title=Man Utd 1–0 Fulham: Zirkzee scores late winner on debut as Man Utd beat Fulham in opener |url=https://www.bbc.co.uk/sport/football/live/cr40634rz5wt |website=BBC Sport |access-date=17 August 2024 |date=16 August 2024}}</ref> Ia melakukan penampilan pertamanya sebagai pemain inti untuk United dalam kekalahan 3-0 dari [[Rivalitas Liverpool F.C. dan Manchester United F.C.|rival]]nya, [[Liverpool F.C.|Liverpool]], di [[Old Trafford]] pada 1 September.[32]<ref>{{cite web |first=David |last=Hytner |url=https://www.theguardian.com/football/article/2024/sep/01/manchester-united-liverpool-premier-league-match-report |title=Luis Díaz strikes twice as dominant Liverpool win at Manchester United |website=The Guardian |date=1 September 2024 |access-date=2 September 2024}}</ref>
Pada 1 Desember, ia mencetak dua gol untuk membantu Manchester United mengamankan kemenangan 4-0 atas [[Everton F.[33C.|Everton]].<ref>{{cite web|first=Nick |last=Wright |url=https://www.skysports.com/amp/football/news/11661/13262409/man-utd-4-0-everton-marcus-rashford-and-joshua-zirkzee-on-target-as-ruben-amorim-gets-first-premier-league-win|title=Man Utd 4-0 Everton: Marcus Rashford and Joshua Zirkzee on target as Ruben Amorim gets first Premier League win|date=2 December 2024 |access-date=2 December 2024}}</ref>
