Mekuitazin: Perbedaan antara revisi
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==Sintesis==
Prekursor yang sama seperti untuk [[kuifenadin]]. Perhatikan bahwa sintesisnya telah berubah selama bertahun-tahun dari aslinya. Satu rute tampaknya melibatkan reaksi Johnson–Corey–Chaykovsky dari keton awal, meskipun rute sekunder lain juga dibahas.
[[File:Mequitazine synthesis.svg|thumb|500px|center|[https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-13-0063 Thieme] Prec:<ref>{{cite patent | inventor = Bondiou JC, Hodac F, Legroux D | country = US | number = 4546185 | gdate = Pharmuka Laboratoires }}</ref> Sinthesis:<ref name="pmid19881287">{{cite journal | vauthors = Gonnot V, Nicolas M, Mioskowski C, Baati R | title = Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate | journal = Chemical & Pharmaceutical Bulletin | volume = 57 | issue = 11 | pages = 1300–2 | date = November 2009 | pmid = 19881287 | doi = 10.1248/cpb.57.1300 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Guminski Y, Fabre V, Lesimple P, Imbert T | title = An efficient synthesis of mequitazine. | journal = Organic Preparations and Procedures International | date = June 1999 | volume = 31 | issue = 3 | pages = 319–323 | doi = 10.1080/00304949909458326 }}</ref><ref name="pmid21657243">{{cite journal | vauthors = Leroux S, Larquetoux L, Nicolas M, Doris E | title = Asymmetric synthesis of (+)-mequitazine from quinine | journal = Organic Letters | volume = 13 | issue = 13 | pages = 3549–51 | date = July 2011 | pmid = 21657243 | doi = 10.1021/ol2012567 }}</ref>]]
==Referensi==
{{Reflist}}
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