Siklus asam sitrat: Perbedaan antara revisi
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Produk dari siklus asam sitrat adalah prekursor bagi berbagai jenis [[senyawa organik]], termasuk [[asam amino]].
== Sekilas proses ==
* Siklus asam sitrat dimulai dengan [[asetil-KoA]] yang mengirimkan [[gugus fungsional|gugus]] [[asetil]] yang mempunyai dua [[atom]] [[karbon]], ke [[senyawa organik|senyawa]] [[asam oksaloasetat]] yang memiliki [[molekul]] dengan empat atom karbon, dan membentuk [[asam sitrat]] dengan enam atom karbon.
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* The citrate then goes through a series of chemical transformations, losing two [[carboxyl]] groups as CO<sub>2</sub>. The carbons lost as CO<sub>2</sub> originate from what was oxaloacetate, not directly from acetyl-CoA. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle. Loss of the acetyl-CoA-donated carbons as CO<sub>2</sub> requires several turns of the citric acid cycle. However, because of the role of the citric acid cycle in anabolism, they may not be lost since many TCA cycle intermediates are also used as precursors for the biosynthesis of other molecules.<ref>Wolfe RR, Jahoor F. (1990) [http://www.ajcn.org/cgi/reprint/51/2/248.pdf Recovery of labeled CO<sub>2</sub> during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation.] ''Am J Clin Nutr.'' '''51(2)''':248-52. PMID 2106256 </ref>
* Most of the energy made available by the oxidative steps of the cycle is transferred as energy-rich [[electrons]] to NAD<sup>+</sup>, forming NADH. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced.
* Electrons are also transferred to the electron acceptor Q, forming QH<sub>2</sub>.
* At the end of each cycle, the four-carbon oxaloacetate has been regenerated, and the cycle continues.
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== Rujukan ==
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