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== Sekilas proses ==
* Siklus asam sitrat dimulai dengan satu [[molekul]] [[asetil-KoA]] yangbereaksi dengan satu molekul H<sub>2</sub>, mengirimkanmelepaskan [[gugus fungsional|gugus]] [[asetilkoenzim-A]], yangdan mempunyaimendonorkan dua sisa [[atom]] [[karbon]], keyang membentuk gugus [[senyawa organik|senyawaasetil]] kepada [[asam oksaloasetat]] yang memiliki [[molekul]] dengan empat atom karbon, dan membentuk [[asam sitrat]] dengan enam atom karbon.<ref>{{en}}{{cite book
| title = Molecular Biology of the Cell - Simple overview of the citric acid cycle
| author = Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter
| url = http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A287&rendertype=figure&id=A305
| accessdate = 2010-07-11
}}</ref><ref>{{en}}{{cite book
| title = Molecular Biology of the Cell - Panel 2-9 The Complete Citric Acid Cycle
| author = Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter
| isbn = 0-8153-3218-1
| edition = 4
| year = 2002
| page =
| publisher = Garland Science
| url = http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A287&rendertype=box&id=A307
| accessdate = 2010-07-14
}}</ref>
* Asam sitrat kemudian mengalami sederet transformasi kimiawi, mengakibatkan dua gugus [[karboksil]] terlepas dari domain oksaloasetat, sebagai CO<sub>2</sub>.
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* The citrate then goes through a series of chemical transformations, losing two [[carboxyl]] groups as CO<sub>2</sub>. The carbons lost as CO<sub>2</sub> originate from what was oxaloacetate, not directly from acetyl-CoA. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle. Loss of the acetyl-CoA-donated carbons as CO<sub>2</sub> requires several turns of the citric acid cycle. However, because of the role of the citric acid cycle in anabolism, they may not be lost since many TCA cycle intermediates are also used as precursors for the biosynthesis of other molecules.<ref>Wolfe RR, Jahoor F. (1990) [http://www.ajcn.org/cgi/reprint/51/2/248.pdf Recovery of labeled CO<sub>2</sub> during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation.] ''Am J Clin Nutr.'' '''51(2)''':248-52. PMID 2106256 </ref>
* At the end of each cycle, the four-carbon oxaloacetate has been regenerated, and the cycle continues.
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* Energi yang dihasilkan dari reaksi oksidasi dikirimkan dalam bentuk [[elektron]] menuju [[Nikotinamida adenina dinukleotida|NAD<sup>+</sup>]], membentuk NADH. Untuk setiap gugus asetil, akan terjadi tiga molekul NADH.
* Elektron juga dikirimkan ke penerima [[flavin adenina dinukleotida|FAD<sup>2+</sup>]], membentuk FADH<sub>2</sub>.
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