Etilmorfin

Etilmorfin
Nama sistematis (IUPAC)
	7,8-didehydro-4,5-α-epoxy- 3-ethoxy-17-methylmorphinan-6-α-ol
Data klinis
Nama dagang	Cosylan, Diolan, Dionina, Diosan, Solvipect, Trachyl
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	Schedule I (CA) ? (UK) Schedule II (US)
Pengenal
Nomor CAS	76-58-4
Kode ATC	R05DA01 S01XA06
PubChem	CID 5359271
DrugBank	DB01466
ChemSpider	4514250
UNII	RWO67D87EU
KEGG	D07929
Data kimia
Rumus	C19H23NO3
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1 ; Key:OGDVEMNWJVYAJL-LEPYJNQMSA-N ;

Etilmorfin (juga dikenal sebagai kodetilin, dionin, dan etil morfin) adalah analgesik dan antitusif opioid.^[1]^[2]^[3]^[4]^[5]^[6]

Efek samping

Dalam budaya masyarakat

Referensi

^ Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J (April 1997). "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology. 80 (4): 171–81. doi:10.1111/j.1600-0773.1997.tb00392.x  . PMID 9140136.
^ Jonasson B, Jonasson U, Holmgren P, Saldeen T (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. PMID 10460420.
^ Popa C, Beck O, Brodin K (March–April 1998). "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology. 22 (2): 142–7. doi:10.1093/jat/22.2.142  . PMID 9547411.
^ Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.
^ Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology. 39 (6): 611–20. doi:10.1111/j.1365-2125.1995.tb05720.x. PMC 1365072  . PMID 7654478.
^ Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. PMC 1364985  . PMID 7756104.

[1] Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J (April 1997). "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology. 80 (4): 171–81. doi:10.1111/j.1600-0773.1997.tb00392.x  . PMID 9140136.

[2] Jonasson B, Jonasson U, Holmgren P, Saldeen T (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. PMID 10460420.

[3] Popa C, Beck O, Brodin K (March–April 1998). "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology. 22 (2): 142–7. doi:10.1093/jat/22.2.142  . PMID 9547411.

[4] Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.

[5] Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology. 39 (6): 611–20. doi:10.1111/j.1365-2125.1995.tb05720.x. PMC 1365072  . PMID 7654478.

[6] Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. PMC 1364985  . PMID 7756104.

[1]

[2]

[3]

[4]

[5]

[6]