Etamsilat

Etamsilat
Nama sistematis (IUPAC)
	2,5-Asam dihidroksibenzenasulfonat; N-etiletanamina
Data klinis
Nama dagang	Cyclonamine, Dicynene, Dicynone, Haemostop, Menostat
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	?
Pengenal
Nomor CAS	2624-44-4
Kode ATC	B02BX01
PubChem	CID 17506
ChemSpider	16553
UNII	24YL531VOH
KEGG	D01282
Sinonim	Dietilamonium 2,5-dihidroksibenzenasulfonat; dietilamonium dobesilat
Data kimia
Rumus	C10H17NO5S
SMILES	eMolecules & PubChem
	InChI InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3 ; Key:HBGOLJKPSFNJSD-UHFFFAOYSA-N ;

Etamsilat adalah agen antihemoragik yang diyakini bekerja dengan meningkatkan resistensi pada endotelium kapiler dan meningkatkan adhesi trombosit.^[1]^[2] Ia juga menghambat biosintesis dan aksi prostaglandin yang menyebabkan disagregasi trombosit, vasodilatasi, dan peningkatan permeabilitas kapiler.^[3]

Etamsilat adalah garam dari asam dobesilat dan dietilamina.

^ Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005). "Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial". Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31–F35. doi:10.1136/adc.2003.035790. PMC 1721806 . PMID 15613570.
^ Elbourne D, Ayers S, Dellagrammaticas H, Johnson A, Leloup M, Lenoir-Piat S (May 2001). "Randomised controlled trial of prophylactic etamsylate: follow up at 2 years of age". Archives of Disease in Childhood. Fetal and Neonatal Edition. 84 (3): F183–F187. doi:10.1136/fn.84.3.F183. PMC 1721248 . PMID 11320045.
^ Kovács L, Falkay G (November 1981). "Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro". Experientia. 37 (11): 1182–1183. doi:10.1007/BF01989908. PMID 7319004.

[pmid15613570-1] Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005). "Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial". Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31–F35. doi:10.1136/adc.2003.035790. PMC 1721806 . PMID 15613570.

[pmid11320045-2] Elbourne D, Ayers S, Dellagrammaticas H, Johnson A, Leloup M, Lenoir-Piat S (May 2001). "Randomised controlled trial of prophylactic etamsylate: follow up at 2 years of age". Archives of Disease in Childhood. Fetal and Neonatal Edition. 84 (3): F183–F187. doi:10.1136/fn.84.3.F183. PMC 1721248 . PMID 11320045.

[pmid7319004-3] Kovács L, Falkay G (November 1981). "Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro". Experientia. 37 (11): 1182–1183. doi:10.1007/BF01989908. PMID 7319004.

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[2]

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