Andrografolid

Andrographolide
Nama
	Nama IUPAC 3-[2-[Dekahidro-6-hidroksi-5-(hidroksimetil)-5,8a-dimetil-2-metilena-1-naptalenil]etilidena]dihidro-4-hidroksi-2(3H)-furanona
Penanda
Nomor CAS	5508-58-7 ;
Model 3D (JSmol)	Gambar interaktif; Gambar interaktif;
3DMet	{{{3DMet}}}
ChEBI	CHEBI:65408 ;
ChEMBL	ChEMBL186141 ;
ChemSpider	16735664 ;
Nomor EC
PubChem CID	5318517;
Nomor RTECS	{{{value}}}
UNII	410105JHGR ;
CompTox Dashboard (EPA)	DTXSID3045980 ;
	InChI InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16+,17-,19+,20?/m1/s1 Key: BOJKULTULYSRAS-FNTFRYDESA-N ; InChI=1/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3 Key: BOJKULTULYSRAS-UHFFFAOYAB; InChI=1/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16+,17-,19+,20?/m1/s1 Key: BOJKULTULYSRAS-FNTFRYDEBY;
	SMILES O=C3OCC(O)C3=CCC1\C(=C)CCC2C(C)(CO)C(O)CCC12C; OC3COC(=O)\C3=C\C[C@@H]1C(=C)CC[C@@H]2C(C)(CO)[C@H](O)CC[C@@]12C;
Sifat
Rumus kimia	C20H30O5
Massa molar	350,46 g·mol−1
Penampilan	Rhombic prisms or plates from ethanol or methanol
Densitas	1.2317 g/cm3
Titik lebur	230 hingga 231 °C (446 hingga 448 °F; 503 hingga 504 K)
Kelarutan dalam air	Sparingly soluble
Senyawa terkait
Related labdanes	14-deoxyandrographolide
Senyawa terkait	Xiyanping
	Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa).
	verifikasi (apa ini ?)
	Referensi

Andrografolid adalah diterpenoid labdana yang telah diisolasi dari batang dan daun sambiloto.^[1] Andrografolid adalah zat yang sangat pahit.

Andrografolid telah dipelajari untuk mengetahui efeknya pada sinyal sel, imunomodulasi, dan strok.^[2] Penelitian telah menunjukkan bahwa andrografolid dapat mengikat spektrum target protein termasuk NF-κB dan aktin melalui modifikasi kovalen.^[3]^[4]

^ Chakravarti RN, Chakravarti D (March 1951). "Andrographolide, the active constituent of Andrographis paniculata Nees; a preliminary communication". The Indian Medical Gazette. 86 (3): 96–7. PMC 5191793 . PMID 14860885.
^ abcamBiochemicals Andrographolide-ab120636
^ Wang J, Tan XF, Nguyen VS, Yang P, Zhou J, Gao M, et al. (March 2014). "A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis". Molecular & Cellular Proteomics. 13 (3): 876–86. doi:10.1074/mcp.M113.029793 . PMC 3945915 . PMID 24445406.
^ Tan WS, Liao W, Zhou S, Wong WS (September 2017). "Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action". Biochemical Pharmacology. 139: 71–81. doi:10.1016/j.bcp.2017.03.024. PMID 28377280.

[1] Chakravarti RN, Chakravarti D (March 1951). "Andrographolide, the active constituent of Andrographis paniculata Nees; a preliminary communication". The Indian Medical Gazette. 86 (3): 96–7. PMC 5191793 . PMID 14860885.

[2] Biochemicals Andrographolide-ab120636

[3] Wang J, Tan XF, Nguyen VS, Yang P, Zhou J, Gao M, et al. (March 2014). "A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis". Molecular & Cellular Proteomics. 13 (3): 876–86. doi:10.1074/mcp.M113.029793 . PMC 3945915 . PMID 24445406.

[pmid28377280-4] Tan WS, Liao W, Zhou S, Wong WS (September 2017). "Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action". Biochemical Pharmacology. 139: 71–81. doi:10.1016/j.bcp.2017.03.024. PMID 28377280.

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