Meksiletin
{{Drugbox | verifiedrevid = 462252080 | image = Mexiletine.svg | width = 200 | alt = | chirality = Racemic mixture
| tradename = Mexitil, NaMuscla | Drugs.com = monograph | MedlinePlus = a607064 | DailyMedID = Mexiletine | pregnancy_AU = B1 | routes_of_administration = Oral, intravena
| legal_CA = Rx-only | legal_CA_comment = [1] | legal_UK = POM | legal_US = Rx-only | legal_EU = Rx-only
| bioavailability = 90% | protein_bound = 50–60% | metabolism = Hati (dimediasi CYP2D6 dan [[CYP1A2|1A2]) | elimination_half-life = 10–12 jam | excretion = Ginjal (10%)
| index2_label = as HCl
| CAS_number_Ref = 
| CAS_number = 31828-71-4
| ATC_prefix = C01
| ATC_suffix = BB02
| PubChem = 4178
| IUPHAR_ligand = 2629
| DrugBank_Ref =
| DrugBank = DB00379
| ChemSpiderID_Ref =
| ChemSpiderID = 4034
| UNII_Ref =
| UNII = 1U511HHV4Z
| KEGG_Ref =
| KEGG = D08215
| KEGG2_Ref =
| KEGG2 = D00639
| ChEBI_Ref =
| ChEBI = 6916
| ChEMBL_Ref =
| ChEMBL = 558
| IUPAC_name = (RS)-1-(2,6-dimetilfenoksi)propan-2-amina
2-(2-aminopropoksi)-1,3-dimetilbenzena
| C=11 | H=17 | N=1 | O=1
| smiles = O(c1c(cccc1C)C)CC(N)C
| StdInChI_Ref =
| StdInChI = 1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
| StdInChIKey_Ref =
| StdInChIKey = VLPIATFUUWWMKC-UHFFFAOYSA-N
}}
Meksiletin (INN) adalah obat yang digunakan untuk mengobati irama jantung abnormal, nyeri kronis, dan beberapa penyebab kekakuan otot. Efek samping yang umum termasuk nyeri perut, ketidaknyamanan dada, kantuk, sakit kepala, dan mual. Obat ini bekerja sebagai penghambat saluran natrium berpagar tegangan non-selektif dan termasuk dalam kelompok obat antiaritmia Kelas IB.[2]
- ^ "Product monograph brand safety updates". Health Canada. February 2024. Diakses tanggal 24 March 2024.