Glukuronosiltransferase
Glusuronosiltransferase (Inggris: 1-naphthol glucuronyltransferase; 1-naphthol-UDP-glucuronosyltransferase; 17β-hydroxysteroid UDP-glucuronosyltransferase; 3α-hydroxysteroid UDP-glucuronosyltransferase; 4-hydroxybiphenyl UDP-glucuronosyltransferase; 4-methylumbelliferone UDP-glucuronosyltransferase; 4-nitrophenol UDP-glucuronyltransferase; 4-nitrophenol UDPGT; 17-OH steroid UDPGT; 3-OH androgenic UDPGT; bilirubin uridine diphosphoglucuronyltransferase; bilirubin UDP-glucuronosyltransferase; bilirubin monoglucuronide glucuronyltransferase; bilirubin UDPGT; bilirubin glucuronyltransferase; ciramadol UDP-glucuronyltransferase; estriol UDP-glucuronosyltransferase; estrone UDP-glucuronosyltransferase; uridine diphosphoglucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase; uridine diphosphoglucuronate-bilirubin glucuronosyltransferase; uridine diphosphoglucuronate-estriol glucuronosyltransferase; uridine diphosphoglucuronate-estradiol glucuronosyltransferase; uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase; uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase; uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase; uridine diphosphoglucuronosyltransferase; GT; morphine glucuronyltransferase; p-hydroxybiphenyl UDP glucuronyltransferase; p-nitrophenol UDP-glucuronosyltransferase; p-nitrophenol UDP-glucuronyltransferase; p-nitrophenylglucuronosyltransferase; p-phenylphenol glucuronyltransferase; phenyl-UDP-glucuronosyltransferase; PNP-UDPGT; UDP glucuronate-estradiol-glucuronosyltransferase; UDP glucuronosyltransferase; UDP glucuronate-estriol glucuronosyltransferase; UDP glucuronic acid transferase; UDP glucuronyltransferase; UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase; UDP-glucuronate-bilirubin glucuronyltransferase; UDP-glucuronosyltransferase; UDP-glucuronyltransferase; UDPGA transferase; UDPGA-glucuronyltransferase; UDPGT; uridine diphosphoglucuronyltransferase; uridine diphosphoglucuronate-bilirubin glucuronosyltransferase; uridine diphosphate glucuronyltransferase; uridine 5'-diphosphoglucuronyltransferase; uridine diphosphoglucuronosyltransferase, UDP-glucuronate β-D-glucuronosyltransferase (acceptor-unspecific), UGT, EC 2.4.1.17)[1] adalah enzim fasa II yang mengkatalis reaksi konjugasi asam glusuronat ke berbagai substrat nukleofilik eksogenus dan endogenus, seperti bilirubin dan estrogen,[2] khususnya konjugasi pada senyawa karsinogenik seperti fenolik, hidrokarbon poliaromatik, amina aromatik. Reaksi konjugasi itu disebut reaksi glusuronidasi, yang biasa terjadi pada lintasan detoksifikasi dengan variasi enzim detoks lain seperti sitokrom P450 dan glutathion S-transferase.
Manusia dengan tingkat glusuronidasi yang rendah, memiliki risiko kanker yang lebih tinggi, karena senyawa hidrokarbon poliaromatik memerlukan konjugasi asam glusuronat agar dapat menjadi inaktif.
UGT-1A1 merupakan enzim utama yang berperan pada proses glusuronidasi estradiol,[3] dengan peningkatan aktivitas pada kanker payudara dan hepatokarsinoma
Rujukan
- ^ (Inggris)"EC 2.4.1.17". Queen Mary University of London. Diakses tanggal 2011-05-18.
- ^ (Inggris)"Glucuronidation and Susceptibility to Chemical Carcinogenesis". Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois; Matthew A. Wallig. Diakses tanggal 2011-05-18.
- ^ (Inggris)"Genetic Polymorphisms in Uridine Diphospho-Glucuronosyltransferase 1A1 and Association with Breast Cancer among African Americans". Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina, School of Public Health, Queensland University of Technology; Chantal Guillemette, Robert C. Millikan, Beth Newman, dan David E. Housman. Diakses tanggal 2011-05-18.
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