CRISPR: Perbedaan antara revisi

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Pierrewee (bicara | kontrib)
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Pierrewee (bicara | kontrib)
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[[File:Crispr.png|thumb|450px|right|Diagram mekanisme pertahanan antiviral prokariota CRISPR.<ref name="pmid20056882">{{cite journal | vauthors = Horvath P, Barrangou R | title = CRISPR/Cas, the immune system of bacteria and archaea | journal = Science | volume = 327 | issue = 5962 | pages = 167–70 | date = January 2010 | pmid = 20056882 | doi = 10.1126/Science.1179555 | bibcode = 2010Sci...327..167H }}</ref>]]
 
'''CRISPR''' (Bahasa Inggris : ''Clustered regularly interspaced short palindromic repeats'', dilafalkan ''crisper''<ref name="sawyer2013">{{cite web | url = http://www.nature.com/scitable/blog/bio2.0/editing_genomes_with_the_bacterial | title = Editing Genomes with the Bacterial Immune System | last = Sawyer | first = Eric | name-list-format = vanc | date = 9 February 2013 | website = Scitable | doi = | pmid = | access-date = 6 April 2015 | publisher = Nature Publishing Group}}</ref>) adalah segmen dari [[DNA]] [[prokariota]] yang mengandung urutan basis pendek, berulang. Dalam suatu pengulangan [[palindromik]], urutan [[nukleotida]] adalah sama dalam kedua arah. Setiap pengulangan diikuti oleh segmen pendek [[spacer DNA]] dari eksposur sebelumnya dari DNA asing (yakni suatu [[phage|virus]] atau [[plasmid]]).<ref name="pmid20125085">{{cite journal | vauthors = Marraffini LA, Sontheimer EJ | title = CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea | journal = Nature Reviews Genetics | volume = 11 | issue = 3 | pages = 181–90 | date = March 2010 | pmid = 20125085 | pmc = 2928866 | doi = 10.1038/nrg2749 }}</ref> Small clusters of ''cas'' (CRISPR-associated system) genes are located next to CRISPR sequences.