Polimiksin B: Perbedaan antara revisi
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{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 414279035
| IUPAC_name = <nowiki>N-[4-amino-1-[[1-[[4-amino-1-okso-1-[[6,9,18-tris(2-aminoetil)-15-benzil-3-(1-hidroksietil)-12-(2-metilpropil)-2,5,8,11,14,17,20-heptaokso-1,4,7,10,13,16,19-heptazasiklotrikos-21-il]amino]butan-2-il]amino]-3-hidroksi-1-oksobutan-2-il]amino]-1-oksobutan-2-il]-6-metiloktanamida</nowiki>
| image = Polymyxin B1.svg
| image2 = polymyxin B2.svg
<!--Clinical data-->
| tradename = Poly-Rx, dll
| Drugs.com = {{drugs.com|monograph|polymyxin-b-sulfate-topical}}
| pregnancy_category = B<ref name=AHFS2019/>
| legal_status = OTC
| routes_of_administration = [[Topikal]], [[Penyuntikan intraotot|intramuskular]], intravena, intratekal, tetes mata
<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1405-20-5
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 19371312D4
| ATC_prefix = A07
| ATC_suffix = AA05
| ATC_supplemental = {{ATC|J01|XB02}} {{ATC|S01|AA18}} {{ATC|S02|AA11}} {{ATC|S03|AA03}} {{ATCvet|J51|XB02}}
| PubChem = 5702105
| NIAID_ChemDB = 007797
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00781
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201283
<!--Chemical data-->
| C=56 | H=100 | N=16 | O=17 | S=1
}}
'''Polimiksin B''' merupakan [[antibiotik]] yang digunakan untuk mengobati [[meningitis]], [[pneumonia]], [[sepsis]], dan [[infeksi saluran kemih]]. Meskipun berguna untuk banyak infeksi bakteri [[gram-negatif]], obat ini tidak berguna untuk infeksi bakteri [[gram-positif]]. Obat ini dapat diberikan melalui [[infus|suntikan]] ke pembuluh darah, otot, atau cairan serebrospinal atau dihirup.<ref name=AHFS2019>{{cite web |title=Polymyxin B Sulfate topical Monograph for Professionals |url=https://www.drugs.com/monograph/polymyxin-b-sulfate-topical.html |website=Drugs.com |access-date=11 November 2019 |language=en}}</ref> Bentuk injeksi umumnya hanya digunakan jika pilihan lain tidak tersedia.<ref name=Ben2009/> Obat ini juga tersedia dalam kombinasi basitrasin/polimiksin B dan neomisin/polimiksin B/basitrasin untuk digunakan pada kulit.<ref name="Triple2019">{{cite web |title=Neomycin, bacitracin, polymyxin b ointment |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26c6ab3e-f4a7-48ea-8b83-fef9d1290638 |access-date=19 April 2019 |work=DailyMed |publisher=U.S. National Library of Medicine}}</ref><ref name=Woo2015>{{cite book | vauthors = Woo TM, Robinson MV |title=Pharmacotherapeutics For Advanced Practice Nurse Prescribers |date=2015 |publisher=F.A. Davis |isbn=9780803645813 |page=651 |url=https://books.google.com/books?id=2Q5hCgAAQBAJ&q=%2B%22most+providers+are+recommending+that+patients+use+double-antibiotic+%28Polysporin%29+rather+than+triple-antibiotic+%28Neomycin%29+products%22&pg=PA651 |language=en}}</ref>
Baris 4 ⟶ 44:
Obat ini ada dalam [[Daftar Obat Esensial Organisasi Kesehatan Dunia]].<ref name="WHO21st">{{cite web |title=World Health Organization model list of essential medicines: 21st list 2019 |date=2019|hdl=10665/325771 | publisher = World Health Organization | url = https://apps.who.int/iris/bitstream/handle/10665/325771/WHO-MVP-EMP-IAU-2019.06-eng.pdf }}</ref> Obat ini tersedia sebagai obat generik.<ref name=AHFS2019/> Di Eropa baru disetujui untuk diterapkan pada kulit pada tahun 2015.<ref>{{cite web |title=Polymyxin-based products | work = Assessment report |url=https://www.ema.europa.eu/en/documents/referral/assessment-report-article-53-procedure-polymyxin-based-products_en.pdf | publisher = European Medicines Agency |access-date=11 November 2019}}</ref> Obat ini berasal dari bakteri ''Paenibacillus polymyxa'' (sebelumnya dikenal sebagai ''Bacillus polymyxa'').<ref name=Ben2009>{{cite book | vauthors = Bennett JE, Dolin R, Blaser MJ, Mandell GL |title=Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book |date=2009 |publisher=Elsevier Health Sciences |isbn=9781437720600 |page=469 |url=https://books.google.com/books?id=uPbHJdSGjPEC&pg=PA469 |language=en}}</ref>
==Kegunaan dalam Medis==
==Mekanisme Kerja==
==Komposisi campuran==
==Aplikasi penelitian==
== Referensi ==
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