Semaglutide: Perbedaan antara revisi
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Baris 1:
{{Infobox drug
| drug_name =
| INN =
| type =<!-- empty -->
| image =Semaglutide.svg
| width =300px
| alt =
| caption =
<!--Names-->
| pronounce =
| tradename =Ozempic, Rybelsus, dan lain-lain
| synonyms =
| IUPAC_name =
<!--External links-->
| Drugs.com ={{Drugs.com|monograph|semaglutide}}
| MedlinePlus = a618008
<!-- Clinical data -->
| class = [[Agonis GLP-1]]<ref name=AHFS2021>{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
| uses = [[Diabetes melitus tipe 2]], [[obesitas]]<ref name=AHFS2021>{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
| side_effects = Mual, muntah, diare, nyeri perut, sembelit, [[ketoasidosis diabetik]], [[Hipoglisemia|gula darah rendah]], dan [[pankreatitis]]<ref name=BNF80>{{cite book | title=BNF|date=September 2020 - March 2021|publisher=BMJ Group and the Pharmaceutical Press|year=|isbn=978-0-85711-369-6|edition=80|location=|pages=738}}</ref><ref name=AHFS2021>{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
| interactions = <!-- notable interactions -->
| pregnancy_AU = D
| pregnancy_AU_comment= <ref name=Preg2021>{{cite web |title=Semaglutide Use During Pregnancy |url=https://www.drugs.com/pregnancy/semaglutide.html |website=Drugs.com |accessdate=16 April 2021 |language=en |archive-date=17 April 2021 |archive-url=https://web.archive.org/web/20210417114123/https://www.drugs.com/pregnancy/semaglutide.html |url-status=live }}</ref>
| pregnancy_US = <!-- A/B/C/D/X/N -->
| pregnancy_category=
| breastfeeding =
| routes_of_administration= [[Injeksi subkutan|Subkutan]], [[Per oral|ditelan]]<ref name=AHFS2021>{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
| onset =
| duration_of_action= 63,6 jam
| defined_daily_dose=
| typical_dose = 0,25 hingga 1 mg secara subkutan setiap minggu<ref name=AHFS2021>{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
| legal_EU =Rx-only
| legal_EU_comment =<ref name="Ozempic EPAR">{{cite web | title=Ozempic EPAR | publisher=[[European Medicines Agency]] (EMA) | url=https://www.ema.europa.eu/en/medicines/human/EPAR/ozempic | access-date=26 September 2020 | archive-date=25 October 2020 | archive-url=https://web.archive.org/web/20201025204658/https://www.ema.europa.eu/en/medicines/human/EPAR/ozempic | url-status=live }}</ref><ref name="Rybelsus EPAR">{{cite web | title=Rybelsus EPAR | website=[[European Medicines Agency]] (EMA) | date=29 January 2020 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/rybelsus | access-date=26 September 2020 | archive-date=14 August 2020 | archive-url=https://web.archive.org/web/20200814215223/https://www.ema.europa.eu/en/medicines/human/EPAR/rybelsus | url-status=live }}</ref>
<!-- Legal status -->
| legal_AU = S4
| legal_AU_comment =
| legal_CA = Rx-only
| legal_DE = <!-- Anlage I, II, III -->
| legal_NZ = <!-- Class A, B, C -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_US = Rx-only
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_status = Dengan resep
| licence_EU =
| licence_US =
<!-- Pharmacokinetic data -->
| bioavailability = 89%
| protein_bound =
| metabolism = [[Proteolisis]]
| metabolites =
| elimination_half-life= 1 week
| excretion = Urin dan feses
<!-- Chemical and physical data -->
| C = 187
| H = 291
| N = 45
| O = 59
| StdInChI = 1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1
| StdInChIKey = DLSWIYLPEUIQAV-CCUURXOWSA-N
| StdInChIKey_Ref = {{stdinchicite|correct|pubchem}}
| SMILES = CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)(C)NC(=O)C(CC6=CN=CN6)N
}}
'''Semaglutide,''' dijual dengan merek '''Ozempic,''' adalah obat yang digunakan untuk mengobati [[diabetes melitus tipe 2]] dan [[Kegemukan|obesitas]].<ref name="AHFS2021">{{Cite web|title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live |access-date=2 April 2021}}</ref> Obat ini tidak digunakan sebagai pilihan pertama dan digunakan sebagai alternatif dari [[metformin]] apabila pengobatan dengan metformin tidak memberikan efek. Namun, Semaglutide dan metformin dapat digunakan bersamaan.<ref name="AHFS2021">{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref><ref name="BNF80">{{Cite book|date=September 2020 - March 2021|year=|title=BNF|location=|publisher=BMJ Group and the Pharmaceutical Press|isbn=978-0-85711-369-6|edition=80|pages=738}}</ref> Semaglutide memiliki dapat memperbalki pengaturan gula darah dalam tubuh, mengurangi risiko [[Penyakit kardiovaskular|penyakit jantung]], dan mengurangi risiko gangguan ginjal.<ref name="AHFS2021">{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref> Obat ini diberikan secara per oral (ditelan) atau [[Penyuntikan subkutan|disuntikkan]] ke tubuh.<ref name="AHFS2021">{{cite web |title=Semaglutide Monograph for Professionals |url=https://www.drugs.com/monograph/semaglutide.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=2 April 2021 |language=en |archive-date=16 January 2021 |archive-url=https://web.archive.org/web/20210116145408/https://www.drugs.com/monograph/semaglutide.html |url-status=live }}</ref>
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