BMPR1B2

BMPR1B
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	3MDY
Pengidentifikasi
Alias	BMPR1B, ALK-6, ALK6, CDw293, AMDD, BDA1D, BDA2, bone morphogenetic protein receptor type 1B, AMD3
ID eksternal	OMIM: 603248 MGI: 107191 HomoloGene: 20322 GeneCards: BMPR1B
Lokasi gen (Tikus)
Kr.	Kromosom 3 (tikus)
Akhir	141,875,186 bp
Ontologi gen
Fungsi molekuler	• transferase activity; • nucleotide binding; • protein kinase activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • transforming growth factor beta receptor activity, type I; • GO:0001948, GO:0016582 Ikatan protein plasma; • SMAD binding; • ATP binding; • transforming growth factor beta-activated receptor activity; • growth factor binding;
Komponen seluler	• komponen integral membran; • HFE-transferrin receptor complex; • membran; • receptor complex; • Membran sel; • integral component of plasma membrane; • neuronal cell body; • Dendrit;
Proses biologis	• eye development; • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; • skeletal system development; • Diferensiasi sel; • limb morphogenesis; • ovarian cumulus expansion; • chondrocyte differentiation; • Fosforilasi; • positive regulation of bone mineralization; • chondrocyte development; • cellular response to BMP stimulus; • BMP signaling pathway; • protein phosphorylation; • negative regulation of chondrocyte proliferation; • cartilage development; • positive regulation of osteoblast differentiation; • transmembrane receptor protein serine/threonine kinase signaling pathway; • retina development in camera-type eye; • positive regulation of cartilage development; • positive regulation of chondrocyte differentiation; • positive regulation of cell differentiation; • ovulation cycle; • camera-type eye development; • inflammatory response; • dorsal/ventral pattern formation; • endochondral bone morphogenesis; • cartilage condensation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • proteoglycan biosynthetic process; • retinal ganglion cell axon guidance; • cellular response to growth factor stimulus; • transforming growth factor beta receptor signaling pathway; • pattern specification process;
	Sumber:Amigo / QuickGO
Ortolog
	658
	12167
	ENSG00000138696
	ENSMUSG00000052430
	O00238
	P36898
	NM_001203; NM_001256792; NM_001256793; NM_001256794
NM_001277216; NM_001277217; NM_001277218; NM_001277220; NM_007560;
	NM_001355043
	NP_001194; NP_001243721; NP_001243722; NP_001243723
NP_001264145; NP_001264146; NP_001264147; NP_001264149; NP_031586;
	NP_001341972
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

BMPR1B2 (Bone morphogenetic protein receptor type IB2) adalah gen yang mengkodekan famili reseptor protein morfogenik tulang dari serin transmembrane/treonin kinase. Ikatan ligan reseptor ini adalah BMPs yang merupakan anggota superfamili TGF-β. BMPs terlibat dalam proses embryogenesis dan pembentukan tulang endokondral. Protein ini memberikan sinyalnya melalui pembentukan kompleks heteromerik dari 2 jenis reseptor serin kinase yang berbeda: reseptor tipe I sekitar 50-55 kD dan tipe II sekitar 70-80 kD. Reseptor tipe II membentuk ikatan ligan saat reseptor tipe I tidak ada, tetapi membutuhkan tipe I untuk proses sinyalisasi, sedangkan tipe II membutuhkan tipe I untuk ikatan ligan. Mutasi pada gen ini memiliki hubungan dengan kejadian hipertensi paru.^[4]^[5]

Referensi sunting

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052430 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "BMPR1B Gene - GeneCards | BMR1B Protein | BMR1B Antibody". www.genecards.org. Diakses tanggal 2020-03-09.
^ Reference, Genetics Home. "BMPR1B gene". Genetics Home Reference (dalam bahasa Inggris). Diakses tanggal 2020-03-09.

Artikel bertopik gen ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000052430 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "BMPR1B Gene - GeneCards | BMR1B Protein | BMR1B Antibody". www.genecards.org. Diakses tanggal 2020-03-09.

[5] Reference, Genetics Home. "BMPR1B gene". Genetics Home Reference (dalam bahasa Inggris). Diakses tanggal 2020-03-09.

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