CD81

Molekul CD81 atau kluster diferensiasi 81 adalah protein yang disandi oleh gen CD81.^[1]^[2] Protein juga dikenal sebagai 26 kDa protein permukaan sel, TAPA-1 (Target of the Antiproliferative Antibody 1), dan Tetraspanin-28 (Tspan-28).

Fungsi

Tempat penempelan/masuknya virus hepatitis C

Protein ini memainan peran penting dalam penempelan dan/atau masuknya virus hepatitis C, berinteraksi dengan heterodimer glikoprotein E1/E2.^[3]

Sebagai protein tumpuan reseptor GPR56

GPR56 adalah reseptor yang termasuk dalam GPCR adhesi yang banyak terlibat dalam perkembangan tumor. CD81 terbukti berperan sebagai protein perancah atau tumpuan (scafolding protein) dalam menstabilkan kompleks GPR56-CD81-Galpha-q/11.^[4]

Referensi

^ "Entrez Gene: CD81 CD81 molecule".
^ Andria ML, Hsieh CL, Oren R, Francke U, Levy S (1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". J Immunol. 147 (3): 1030–6. PMID 1650385.
^ Bartosch B, Vitelli A, Granier C, Goujon C, Dubuisson J, Pascale S, Scarselli E, Cortese R, Nicosia A, Cosset FL. "Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor". J Biol Chem. 278 (43): 41624–30. doi:10.1074/jbc.M305289200. PMID 12913001.
^ Little KD, Hemler ME, Stipp CS (2004). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association". Mol Biol Cell. 15 (5): 2375–87. PMC 404030  . PMID 15004227.

[entrez-1] "Entrez Gene: CD81 CD81 molecule".

[pmid1650385-2] Andria ML, Hsieh CL, Oren R, Francke U, Levy S (1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". J Immunol. 147 (3): 1030–6. PMID 1650385.

[pmid12913001-3] Bartosch B, Vitelli A, Granier C, Goujon C, Dubuisson J, Pascale S, Scarselli E, Cortese R, Nicosia A, Cosset FL. "Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor". J Biol Chem. 278 (43): 41624–30. doi:10.1074/jbc.M305289200. PMID 12913001.

[4] Little KD, Hemler ME, Stipp CS (2004). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association". Mol Biol Cell. 15 (5): 2375–87. PMC 404030  . PMID 15004227.

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