CREB3

CREB3
Pengidentifikasi
Alias	CREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
ID eksternal	OMIM: 606443 MGI: 99946 HomoloGene: 31375 GeneCards: CREB3
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • homodimerisasi protein; • protein dimerization activity; • cAMP response element binding protein binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • CCR1 chemokine receptor binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • cAMP response element binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Komponen seluler	• sitoplasma; • komponen integral membran; • nuclear body; • endoplasmic reticulum membrane; • membran; • integral component of endoplasmic reticulum membrane; • neuronal cell body; • Retikulum endoplasma; • Inti sel; • sitosol; • Golgi membrane; • nucleoplasm; • badan Golgi;
Proses biologis	• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • release from viral latency; • positive regulation of cell migration; • cytoplasmic sequestering of transcription factor; • negative regulation of cell cycle; • positive regulation of monocyte chemotaxis; • transcription, DNA-templated; • response to endoplasmic reticulum stress; • induction of positive chemotaxis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • chemotaxis; • response to unfolded protein; • regulation of cell population proliferation; • regulation of cell growth; • establishment of viral latency; • positive regulation of deacetylase activity; • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; • GO:0022415 viral process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of defense response to virus by host; • positive regulation of calcium ion transport; • transcription by RNA polymerase II; • endoplasmic reticulum unfolded protein response; • regulation of apoptotic process;
	Sumber:Amigo / QuickGO
Ortolog
	10488
	12913
	ENSG00000107175
	ENSMUSG00000028466
	O43889
	Q61817
	NM_006368
	NM_013497
	NP_006359
	n/a
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Cyclic AMP-responsive element-binding protein 3 (CREB3) adalah protein yang pada manusia dikodekan oleh gen CREB3.^[3]^[4]

Gen ini mengkodekan faktor transkripsi yang merupakan anggota keluarga protein pengikat DNA leusin. Protein ini mengikat elemen responsif cAMP, palindrom oktamerik. Protein tersebut berinteraksi dengan faktor C1 sel inang, yang juga terkait dengan protein virus herpes simpleks (HSV) VP16 yang menginduksi transkripsi gen HSV. Protein dan VP16 ini mengikat situs yang sama pada faktor sel inang C1. Diperkirakan bahwa interaksi antara protein ini dan faktor C1 sel inang berperan dalam pembentukan latensi selama infeksi HSV. Varian transkrip tambahan telah diidentifikasi, tetapi validitas biologisnya belum ditentukan.^[4]