PCK1

PCK1
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Pengidentifikasi
Alias	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
ID eksternal	OMIM: 614168 MGI: 97501 HomoloGene: 1944 GeneCards: PCK1
Lokasi gen (Tikus)
Kr.	Kromosom 2 (tikus)
Akhir	173,001,066 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• nucleotide binding; • manganese ion binding; • GDP binding; • phosphoenolpyruvate carboxykinase activity; • GTP binding; • metal ion binding; • carboxylic acid binding; • purine nucleotide binding; • lyase activity; • carboxy-lyase activity; • magnesium ion binding; • phosphoenolpyruvate carboxykinase (GTP) activity;
Komponen seluler	• sitoplasma; • sitosol; • extracellular exosome;
Proses biologis	• glucose homeostasis; • internal protein amino acid acetylation; • metabolisme lipid; • response to activity; • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; • oxaloacetate metabolic process; • response to insulin; • Gliseroneogenesis; • cellular response to potassium ion starvation; • cellular response to retinoic acid; • response to lipid; • respons seluler terhadap hipoksia; • cellular response to fructose stimulus; • response to interleukin-6; • glucose metabolic process; • GO:0010260 penuaan; • response to methionine; • cellular response to interleukin-1; • cellular response to glucagon stimulus; • cellular response to cAMP; • cellular response to insulin stimulus; • cellular response to tumor necrosis factor; • response to lipopolysaccharide; • Glukoneogenesis;
	Sumber:Amigo / QuickGO
Ortolog
	5105
	18534
	ENSG00000124253
	ENSMUSG00000027513
	P35558
	Q9Z2V4
	NM_002591
	NM_011044
	NP_002582
	NP_035174
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Phosphoenolpyruvate carboxykinase 1 (larut), juga dikenal sebagai PCK1, adalah sebuah enzim yang pada manusia adalah oleh gen PCK1 .^[4]^[5]

Fungsi sunting

Enzim ini merupakan titik kontrol utama pada peraturan glukoneogenesis. Enzim sitosolik yang dikodekan oleh gen ini, bersama dengan GTP, mengkatalisis pembentukan phosphoenolpyruvate dari oksaloasetat, pada saat pelepasan karbon dioksida dan PDB. Ekspresi gen ini dapat diatur oleh insulin, glukokortikoid, glukagon, cAMP, dan diet. Mitokondria isozim dari protein yang sudah dikodekan juga telah ditandai.

Interaktif peta jalur sunting

Klik pada gen, protein dan metabolit di bawah untuk menghubungkan ke artikel masing-masing. ^{[§ 1]}

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Glycolysis and Gluconeogenesis edit

^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

Referensi sunting

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027513 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".
^ Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743.

[WikiPathways-6] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000027513 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".

[pmid1492743-5] Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743.

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