Penghalang saluran klorida

Penghalang saluran klorida adalah jenis obat yang menghambat transmisi ion (Cl⁻) melalui saluran klorida.

Asam niflumat adalah salah satu penghalang saluran klorida yang telah digunakan dalam penelitian ilmiah eksperimental.^[1] Contoh lainnya adalah asam antrasena-9-karboksilat, penghalang saluran-klorida tipe-CLCN1 kuat yang ditemukan di otot rangka, yang digunakan untuk mempelajari model hewan myotonia congenita.^[2]

Beberapa antagonis reseptor glisina dan reseptor GABAA juga bertindak sebagai penghalang saluran klorida.

Lihat pula

Pembuka saluran klorida

Referensi

^ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658  . PMID 6736917.
^ Villegas-Navarro A, Martinez-Morales M, Morales-Aguilera A (Maret 1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Thérapie. 280 (1): 5–21. PMID 3718080.

Bacaan lebih lanjut

Phillis JW, Song D, O'Regan MH (Januari 1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research. 780 (2): 352–5. doi:10.1016/S0006-8993(97)01352-8. PMID 9507191.
Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl; Savio, Dawn; Huang, Minxue; Fuller, Catherine; Tomer, Yaniv; Nicolaides, Nicholas C.; McLane, Michael; Levitt, Roy C. (2002). "A Calcium‐Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. 248. hlm. 150–170. doi:10.1002/0470860790.ch10. ISBN 9780470844786.
Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M (2004). "Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil--a GABAA-gated chloride channel blocker". Journal of Toxicology. Clinical Toxicology. 42 (7): 955–63. doi:10.1081/CLT-200041784. PMC 1351141  . PMID 15641641.
Lukacs GL, Nanda A, Rotstein OD, Grinstein S (Agustus 1991). "The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells". FEBS Letters. 288 (1–2): 17–20. doi:10.1016/0014-5793(91)80992-C  . PMID 1652470.
Kang JX, Man SF, Brown NE, Labrecque PA, Clandinin MT (Agustus 1992). "The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells". The Biochemical Journal. 285 ( Pt 3) (3): 725–9. doi:10.1042/bj2850725. PMC 1132855  . PMID 1323271.
Liu J, Lai ZF, Wang XD, Tokutomi N, Nishi K (April 1998). "Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells". Journal of Cardiovascular Pharmacology. 31 (4): 558–67. doi:10.1097/00005344-199804000-00014  . PMID 9554805.

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[pmid6736917-1] Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658  . PMID 6736917.

[2] Villegas-Navarro A, Martinez-Morales M, Morales-Aguilera A (Maret 1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Thérapie. 280 (1): 5–21. PMID 3718080.

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