Penapis tumor: Perbedaan antara revisi

* Spesifisitas/kekhasan, hanya [[penapis tumor [[M2-PK]] untuk kanker usus besar yang mencapai 95% spesifisitas

* Paru-paru: CEA, CA 19-9, CA 125, NSE, Cyfra 21-1 (Pada 95% persentil sensivitas Cyfra 21-1 adalah 79%, sedangkan untuk SCC dan CEA adalah 41% dan 31% berturut-turut)<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmed/9072992 |title=Diagnostic value of SCC, CEA and CYFRA 21.1 in lung cancer: a Bayesian analysis |accessdate=August 6, 2014}}</ref> Ternyata penapis tumor M2-PK juga berguna untuk menapis kanker paru-paru dan lebih baik daripada SCC dan NSE,<ref>{{cite journal |pmid=17882813 |year=2007 |last1=Oremek |first1=G |last2=Kukshaĭte |first2=R |last3=Sapoutzis |first3=N |last4=Ziolkovski |first4=P |title=The significance of TU M2-PK tumor marker for lung cancer diagnostics |volume=85 |issue=7 |pages=56–8 |journal=Klinicheskaia meditsina}}</ref>[[en:Tumor M2-PK]] sehingga jika diperkirakan masih normal, cukup melakukan penapisan tumor menggunakan M2-PK saja.

Ternyata penapis tumor M2-PK memiliki banyak peran seperti pada: [[kanker usus besar]],<ref name=Haug2007>{{cite journal |doi=10.1038/sj.bjc.6603712 |title=Tumour M2-PK as a stool marker for colorectal cancer: Comparative analysis in a large sample of unselected older adults vs colorectal cancer patients |year=2007 |last1=Haug |first1=U |last2=Rothenbacher |first2=D |last3=Wente |first3=M N |last4=Seiler |first4=C M |last5=Stegmaier |first5=C |last6=Brenner |first6=H |journal=British Journal of Cancer}}</ref> [[kanker payudara]],<ref>{{cite journal |pmid=11326672 |year=2000 |last1=Lüftner |first1=D |last2=Mesterharm |first2=J |last3=Akrivakis |first3=C |last4=Geppert |first4=R |last5=Petrides |first5=PE |last6=Wernecke |first6=KD |last7=Possinger |first7=K |title=Tumor type M2 pyruvate kinase expression in advanced breast cancer |volume=20 |issue=6D |pages=5077–82 |journal=Anticancer research}}</ref><ref>{{cite journal |pmid=20592362 |year=2010 |last1=Benesch |first1=C |last2=Schneider |first2=C |last3=Voelker |first3=HU |last4=Kapp |first4=M |last5=Caffier |first5=H |last6=Krockenberger |first6=M |last7=Dietl |first7=J |last8=Kammerer |first8=U |last9=Schmidt |first9=M |title=The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer |volume=30 |issue=5 |pages=1689–94 |journal=Anticancer research }}</ref> [[renal cell carcinoma]]<ref>{{cite journal |pmid=11326675 |year=2000 |last1=Oremek |first1=GM |last2=Sapoutzis |first2=N |last3=Kramer |first3=W |last4=Bickeböller |first4=R |last5=Jonas |first5=D |title=Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma |volume=20 |issue=6D |pages=5095–8 |journal=Anticancer research}}</ref><ref>{{cite journal |pmid=10470199 |year=1999 |last1=Wechsel |first1=HW |last2=Petri |first2=E |last3=Bichler |first3=KH |last4=Feil |first4=G |title=Marker for renal cell carcinoma (RCC): The dimeric form of pyruvate kinase type M2 (Tu M2-PK) |volume=19 |issue=4A |pages=2583–90 |journal=Anticancer research}}</ref> [[kanker paru-paru]],<ref>{{cite journal |pmid=12624710 |year=2003 |last1=Schneider |first1=J |last2=Peltri |first2=G |last3=Bitterlich |first3=N |last4=Philipp |first4=M |last5=Velcovsky |first5=HG |last6=Morr |first6=H |last7=Katz |first7=N |last8=Eigenbrodt |first8=E |title=Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients |volume=2 |issue=4 |pages=185–91 |doi=10.1007/s102380300005 |journal=Clinical and experimental medicine}}</ref><ref>{{cite journal |pmid=17882813 |year=2007 |last1=Oremek |first1=G |last2=Kukshaĭte |first2=R |last3=Sapoutzis |first3=N |last4=Ziolkovski |first4=P |title=The significance of TU M2-PK tumor marker for lung cancer diagnostics |volume=85 |issue=7 |pages=56–8 |journal=Klinicheskaia meditsina}}</ref> [[kanker pankreas]],<ref>{{cite journal |pmid=11326648 |year=2000 |last1=Hardt |first1=PD |last2=Ngoumou |first2=BK |last3=Rupp |first3=J |last4=Schnell-Kretschmer |first4=H |last5=Kloer |first5=HU |title=Tumor M2-pyruvate kinase: A promising tumor marker in the diagnosis of gastro-intestinal cancer |volume=20 |issue=6D |pages=4965–8 |journal=Anticancer research}}</ref> [[Esophageal Cancer]],<ref name="DoiMEGbef">{{cite journal |doi=10.1097/MEG.0b013e3280102f78 |title=Tumour M2-pyruvate kinase: A gastrointestinal cancer marker |year=2007 |last1=Kumar |first1=Yogesh |last2=Tapuria |first2=Niteen |last3=Kirmani |first3=Naveed |last4=Davidson |first4=Brian R. |journal=European Journal of Gastroenterology & Hepatology |volume=19 |issue=3 |pages=265}}</ref> [[kanker lambung]],<ref name="DoiMEGbef" /> [[kanker mulut rahim]],<ref>{{cite journal |pmid=15210041 |year=2004 |last1=Kaura |first1=B |last2=Bagga |first2=R |last3=Patel |first3=FD |title=Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for cervical carcinoma |volume=30 |issue=3 |pages=193–6 |doi=10.1111/j.1447-0756.2004.00187.x |journal=The journal of obstetrics and gynaecology research}}</ref> [[kanker indung telur]],<ref>{{cite journal |pmid=17479666 |year=2007 |last1=Ahmed |first1=AS |last2=Dew |first2=T |last3=Lawton |first3=FG |last4=Papadopoulos |first4=AJ |last5=Devaja |first5=O |last6=Raju |first6=KS |last7=Sherwood |first7=RA |title=M2-PK as a novel marker in ovarian cancer. A prospective cohort study |volume=28 |issue=2 |pages=83–8 |journal=European journal of gynaecological oncology}}</ref> Oleh karena itu untuk tes awal atau diperkirakan pasien masih belum memiliki tumor/kanker apapun, cukup dilakukan tes M2-PK dan bukannya CEA yang lebih murah, tetapi tingkat sensitivitasnya sangat rendah.