Triazavirin

Triazavirin
Nama sistematis (IUPAC)
	2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4H)-one
Data klinis
Kat. kehamilan	?
Status hukum	? (US)
Pengenal
Nomor CAS	928659-17-0
Kode ATC	?
PubChem	CID 3113817
ChemSpider	2367718
Data kimia
Rumus	C5H4N6O3S
Massa mol.	228.189
SMILES	eMolecules & PubChem
	InChI InChI=1S/C5H4N6O3S/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5/h1H3,(H,6,8,9); Key:IDVQGNMSSHPZSJ-UHFFFAOYSA-N;

Triazavirin (TZV, Riamilovir) adalah antivirus analog nukleotida yang awalnya dikembangkan di Rusia yang telah menunjukkan kemanjuran terhadap influenza A dan B, termasuk strain H5N1.^[1]^[2]^[3]^[4] Menurut riset, Triazavirin nampaknya mampu mengurangi dampak dari penyakit flu dan juga komplikasi penyakit terkait.^[5] Antivirus ini memiliki inti dari novel triazolotriazine, yang mewakili kelas struktural baru dari obat-obatan antivirus non-nukleosida.^[6]

Manfaat

Triazavirin, yang dikembangkan di Yekaterinburg’s Ural Federal University, awalnya dikembangkan untuk menangani virus ‘Flu Burung’ (H5N1), dank arena adanya persamaan antar kedua virus, para peneliti merasa perlu untuk mencoba khasiat obatnya pada pasien corona.^[7]

Referensi

^ Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.
^ Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869  . PMID 16115318.
^ Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629  . PMID 20194696.
^ Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.
^ "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.
^ Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.
^ Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.

[1] Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.

[2] Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869  . PMID 16115318.

[3] Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629  . PMID 20194696.

[4] Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.

[5] "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.

[6] Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.

[loginova-7] Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.

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