Asam folat

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| Name = Asam folat | ImageFile = Folicacid2.png | ImageSize = 250px | ImageName = Folic acid | IUPACName = (2S)-2-[(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | OtherNames = N-​(4-​{[(2-​amino-​4-​oxo-​1,​4-​dihydropteridin-​6-​yl)​methyl]​amino}​benzoyl)-​L-​glutamic acid; pteroyl-L-glutamic acid; Vitamin B₉; Vitamin M; Folacin | Section1 = ! colspan=2 style="background: #f8eaba; text-align: center;" |Penanda

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Nomor CAS

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• 59-30-3 ^N

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Model 3D (JSmol)

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• Gambar interaktif

|- | 3DMet | {{{3DMet}}} |-

| Nomor EC | |-

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PubChem CID

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• 6037

|- | Nomor RTECS | {{{value}}} |-

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CompTox Dashboard (EPA)

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• DTXSID0022519

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| colspan="2" |

SMILES

• C1=CC(=CC=C1C(=O)NC
  (CCC(=O)O)C(=O)O)
  NCC2=CN=C3C(=N2)
  C(=O)N=C(N3)N

|- | Section2 = ! colspan=2 style="background: #f8eaba; text-align: center;" |Sifat

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Rumus kimia

| C₁₉H₁₉N₇O₆

|- | Massa molar

| 441,40 g·mol⁻¹

|- | Penampilan | bubuk krital berwarna oranye-kekuning-kuningan |-

| Titik lebur | 250 °C (523 K), decomp.

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Kelarutan dalam air

| 0.0016 mg/ml (25 °C) |-

| Keasaman (pK_a) | 1^st: 2.3, 2^nd: 8.3 |- | Section7 = ! colspan=2 style="background: #f8eaba; text-align: center;" |Bahaya

|- | Bahaya utama | non-toxic, non-flammable |- }}

Folic acid (also known as Vitamin B9 or Folacin) and Folate (the naturally occuring form) are forms of the water-soluble Vitamin B₉. Vitamin B9 (Folic acid and Folate inclusive) is essential to numerous bodily functions ranging from nucleotide synthesis to the remethylation of homocysteine. It is especially important during periods of rapid cell division and growth. Both children and adults require folic acid to produce healthy red blood cells and prevent anemia. Folate and Folic acid derive their names from the Latin word folium (leaf).

Folate in foods and other sources

Leafy vegetables such as spinach, turnip greens, lettuces, dried beans and peas, fortified cereal products, sunflower seeds and certain other fruits and vegetables are rich sources of folate. Liver and liver products also contain high amounts of folate, as does baker's yeast. Some breakfast cereals (ready-to-eat and others) are fortified with 25% to 100% of the recommended dietary allowance (RDA) for folic acid. A table of selected food sources of folate and folic acid can be found at the USDA National Nutrient Database for Standard Reference. Folic acid is added to grain products in many countries, and in these countries fortified products make up a significant source of folate . Because of the difference in bioavailability between supplemented folic acid and the different forms of folate found in food, the dietary folate equivalent (DFE) system was established. 1 DFE is defined as 1 μg of dietary folate, or 0.6 μg of folic acid supplement. This is reduced to 0.5 μg of folic acid if the supplement is taken on an empty stomach.

Asam folat adalah bentuk dari vitamin B yang larut dalam air. Asam ini terdapat secara alamiah dalam makanan dan dapat juga dimakan sebagai suplemen. Nama "folat" berasal dari kata bahasa Latin folium (daun).

Folat dalam makanan

Sayur berdaun seperti bayam dan lobak cina, kacang kering dan kacang polong, sereal, biji bunga matahari dan buah dan sayuran lainnya adalah sumber yang kaya folat.

Sejarah

Pengamatan kunci oleh peneliti Lucy Wills pada 1931 menyatakan bahwa pengidentifikasian folat sebagai nutrisi yang dibutuhkan untuk mencegah anemia pada saat kehamilan. Dr. Wills menunjukkan bahwa anemia dapat disembuhkan dengan khamir alkohol. Folat disintesis pada tahun 1946.