Lanatosida C

Lanatosida C
Nama sistematis (IUPAC)
	(3β,5β,12β)- 3-{[β-D- glukopiranosil- (1→4)- 3-O-asetil- 2,6-dideoksi- β-D-ribo- heksopiranosil- (1→4)- 2,6-dideoksi- β-D- ribo- heksopiranosil- (1→4)- 2,6-dideoksi- β-D- ribo- heksopiranosil]oksi}- 12,14-dihidroksikard- 20(22)- enolida
Data klinis
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	?
Rute	Oral, intravena
Pengenal
Nomor CAS	17575-22-3
Kode ATC	C01AA06
PubChem	CID 656630
ChemSpider	570984
UNII	5RR3JFZ771
KEGG	D01972
ChEMBL	CHEMBL506569
Sinonim	[6-[6-[6-[[12,14-dihidroksi- 10,13-dimetil- 17-(5-okso-2H-furan-3-il)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradekahidrosiklopenta[a]fenantren- 3-il]oksi]- 4-hidroksi- 2-metiloksan- 3-il]oksi- 4-hidroksi- 2-metiloksan-3-il]oksi- 2-metil- 3-[3,4,5-trihidroksi- 6-(hidroksimetil)oksan-2-yl]oksioksan- 4-il] asetat
Data kimia
Rumus	C49H76O20
SMILES	eMolecules & PubChem
	InChI InChI=1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1 ; Key:JAYAGJDXJIDEKI-PTGWOZRBSA-N ;

Lanatosida C (atau isolanid) adalah glikosida jantung, jenis obat yang dapat digunakan dalam pengobatan gagal jantung kongestif dan aritmia jantung (detak jantung tidak teratur). Lanatoside C dapat digunakan secara oral^[1] atau melalui rute intravena.^[2] Obat ini dipasarkan di sejumlah negara dan juga tersedia dalam bentuk generik.^[3] Obat ini ditemukan di Digitalis lanata.^[4]

Kimia

Zat ini terdiri dari empat monosakarida (glukosa, 3-asetildigitoksosa dan dua digitoksosa) dan aglikon bernama digoksigenin.^[5]

Referensi

^ Lypka A, Lazowski J (September 1979). "[Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomosci Lekarskie (dalam bahasa Polish). 32 (18): 1277–81. PMID 506267.
^ Tàmmaro AE, Baldoli C (January 1967). "[On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (dalam bahasa Italian). 40 (2): 157–61. PMID 5600177.
^ "Lanatoside C". International Drug Names. Drugs.com.
^ Ikeda Y, Fujii Y, Yamazaki M (June 1992). "Determination of Lanatoside C and Digoxin in Digitalis lanata by HPLC and its Application to Analysis of the Fermented Leaf Powder". Journal of Natural Products. 55 (6): 748–52. doi:10.1021/np50084a007.
^ Desai UR (2005). "Cardiac Glycosides". VCU School of Pharmacy.

[1] Lypka A, Lazowski J (September 1979). "[Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomosci Lekarskie (dalam bahasa Polish). 32 (18): 1277–81. PMID 506267.

[2] Tàmmaro AE, Baldoli C (January 1967). "[On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (dalam bahasa Italian). 40 (2): 157–61. PMID 5600177.

[3] "Lanatoside C". International Drug Names. Drugs.com.

[4] Ikeda Y, Fujii Y, Yamazaki M (June 1992). "Determination of Lanatoside C and Digoxin in Digitalis lanata by HPLC and its Application to Analysis of the Fermented Leaf Powder". Journal of Natural Products. 55 (6): 748–52. doi:10.1021/np50084a007.

[5] Desai UR (2005). "Cardiac Glycosides". VCU School of Pharmacy.

[1]

[2]

[3]

[4]

[5]