Isokonazol

Isokonazol
Nama sistematis (IUPAC)
	(RS)-1-[2-[(2,6-Diklorobenzil)oksi]-2-(2,4-diklorofenil)etil]-1H-imidazola
Data klinis
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	?
Pengenal
Nomor CAS	27523-40-6
Kode ATC	D01AC05 G01AF07
PubChem	CID 3760
DrugBank	DB08943
ChemSpider	3629
UNII	GRI7WFR424
KEGG	D04624
ChEBI	CHEBI:82865
ChEMBL	CHEMBL1571863
Data kimia
Rumus	C18H14Cl4N2O
SMILES	eMolecules & PubChem

Isokonazol adalah obat antijamur azola dan dapat menghambat bakteri gram-positif.^[1]^[2] Untuk infeksi kaki dan vagina, isokonazol memiliki efektivitas yang sama dengan klotrimazol.^[3]^[4] Isokonazol nitrat dapat digunakan dalam kombinasi dengan kortikosteroid diflukortolon untuk meningkatkan bioavailabilitasnya.^[1] Obat ini dipatenkan pada tahun 1968 dan disetujui untuk penggunaan medis pada tahun 1979.^[5]

Referensi

^ ^a ^b Veraldi S (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 (Suppl 1): 3–15. doi:10.1111/myc.12054. PMID 23574019.
^ Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). "Isoconazole". Dalam Budavari S. The Merck Index (edisi ke-12th). hlm. 5176. ISBN 0-911910-12-3.
^ Oyeka CA, Gugnani HC (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–361. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.
^ Cohen L (February 1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases. 60 (1): 42–44. doi:10.1136/sti.60.1.42. PMC 1046268  . PMID 6365236.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 502. ISBN 9783527607495.

[Veraldi2013-1] Veraldi S (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 (Suppl 1): 3–15. doi:10.1111/myc.12054. PMID 23574019.

[2] Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). "Isoconazole". Dalam Budavari S. The Merck Index (edisi ke-12th). hlm. 5176. ISBN 0-911910-12-3.

[Oyeka1992-3] Oyeka CA, Gugnani HC (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–361. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.

[Cohen1984-4] Cohen L (February 1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases. 60 (1): 42–44. doi:10.1136/sti.60.1.42. PMC 1046268  . PMID 6365236.

[Fischer2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 502. ISBN 9783527607495.

[1]

[2]

[3]

[4]

[5]