Putresina

Putresina
Nama
	Nama IUPAC (preferensi) Butane-1,4-diamine
	Nama lain 1,4-Diaminobutane
Penanda
Nomor CAS	110-60-1 ;
Model 3D (JSmol)	Gambar interaktif;
3DMet	{{{3DMet}}}
Referensi Beilstein	605282
ChEBI	CHEBI:17148 ;
ChEMBL	ChEMBL46257 ;
ChemSpider	13837702 ;
DrugBank	DB01917 ;
Nomor EC
Referensi Gmelin	1715
IUPHAR/BPS	2388;
KEGG	C02896 ;
MeSH	Putrescine
PubChem CID	1045;
Nomor RTECS	{{{value}}}
Nomor UN	2928
CompTox Dashboard (EPA)	DTXSID4041107 ;
	InChI InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2 Key: KIDHWZJUCRJVML-UHFFFAOYSA-N ;
	SMILES NCCCCN;
Sifat
Rumus kimia	C4H12N2
Massa molar	88,15 g·mol−1
Penampilan	Kristal tak berwarna
Bau	kuat, mirip piperidina
Densitas	0,877 g/mL
Titik lebur	27,5 °C (81,5 °F; 300,6 K)
Titik didih	158,6 °C; 317,4 °F; 431,7 K
Kelarutan dalam air	Tercampur
log P	−0,466
Indeks bias (nD)	1,457
Bahaya
Piktogram GHS
Keterangan bahaya GHS	{{{value}}}
Pernyataan bahaya GHS	H228, H302, H312, H314, H331
Langkah perlindungan GHS	P210, P261, P280, P305+351+338, P310
Titik nyala	51 °C (124 °F; 324 K)
Ambang ledakan	0,98–9,08%
	Dosis atau konsentrasi letal (LD, LC):
LD50 (dosis median)	463 mg kg−1 (oral, tikus); 1.576 g kg−1 (dermal, kelinci);
Senyawa terkait
	Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa).
	verifikasi (apa ini ?)
	Referensi

Putresina, atau tetramethylenediamine, adalah suatu senyawa kimia organik N H₂(CH₂)₄NH₂ (1,4-diaminobutane or butanediamine) yang berbau busuk^[1] yang berhuungan dengan kadaverina; keduanya dihasilkan melalui pemecahan asam amino dalam organisme hidup dan mati dan keduanya merupakan racun dalam dosis besar.^[2]^[3] Kedua senyawa tersebut sebagian besar bertanggung jawab atas bau busuk dari daging yang membusuk, namun juga berperan pada bau dari proses seperti bau napas tidak sedap dan vaginosis bakterialis.^[4] Mereka juga ditemukan dalam semen dan beberapa mikroalga, bersama dengan molekul terkait seperti spermina dan spermidin.

Sejarah

Putresina^[5] dan kadaverina^[6] pertama kali dilaporkan pada 1885 oleh seorang dokter Berlin, Ludwig Brieger (1849–1919).^[7]

Referensi

^ Haglund, William (1996). Forensic taphonomy: The Postmortem Fate of Human Remains. CRC Press. hlm. 100. ISBN 0-8493-9434-1.
^ Lewis, Robert Alan (1998). Lewis' Dictionary of Toxicology. CRC Press. hlm. 212. ISBN 1-56670-223-2.
^ Kamhi, Ellen, Ph.D., RN, HNC (2007). Alternative Medicine Magazine's Definitive Guide to Weight Loss. Celestial Arts. hlm. 14. ISBN 1-58761-259-3. Ornithine is converted by bowel bacteria into a toxic substance called putrescine, which in turn degrades into polyamines, such as spermadine, spermine, and cadaverine (literally meaning "the essence of dead cadavers").
^ Yeoman, CJ;Thomas, SM; Miller, ME; Ulanov, AV; Torralba, M; Lucas, S; Gillis, M; Cregger, M; Gomez, A; Ho, M; Leigh, SR; Stumpf, R; Creedon, DJ; Smith, MA; Weisbaum, JS; Nelson, KE; Wilson, BA; White, BA (2013). "A multi-omic systems-based approach reveals metabolic markers of bacterial vaginosis and insight into the disease". PLOS ONE. 8 (2): e56111. doi:10.1371/journal.pone.0056111. PMC 3566083  . PMID 23405259.
^ Ludwig Brieger, "Weitere Untersuchungen über Ptomaine" [Further investigations into ptomaines] (Berlin, Germany: August Hirschwald, 1885), page 43. From page 43: Ich nenne dasselbe Putrescin, von putresco, faul werden, vermodern, verwesen. (I call this [compound] "putrescine", from [the Latin word] putresco, to become rotten, decay, rot.)
^ Ludwig Brieger, "Weitere Untersuchungen über Ptomaine" [Further investigations into ptomaines] (Berlin, Germany: August Hirschwald, 1885), page 39.
^ Brief biography of Ludwig Brieger (in German). Biography of Ludwig Brieger in English.

Pranala luar

Putrescine MS Spectrum

[1] Haglund, William (1996). Forensic taphonomy: The Postmortem Fate of Human Remains. CRC Press. hlm. 100. ISBN 0-8493-9434-1.

[2] Lewis, Robert Alan (1998). Lewis' Dictionary of Toxicology. CRC Press. hlm. 212. ISBN 1-56670-223-2.

[3] Kamhi, Ellen, Ph.D., RN, HNC (2007). Alternative Medicine Magazine's Definitive Guide to Weight Loss. Celestial Arts. hlm. 14. ISBN 1-58761-259-3. Ornithine is converted by bowel bacteria into a toxic substance called putrescine, which in turn degrades into polyamines, such as spermadine, spermine, and cadaverine (literally meaning "the essence of dead cadavers").

[4] Yeoman, CJ;Thomas, SM; Miller, ME; Ulanov, AV; Torralba, M; Lucas, S; Gillis, M; Cregger, M; Gomez, A; Ho, M; Leigh, SR; Stumpf, R; Creedon, DJ; Smith, MA; Weisbaum, JS; Nelson, KE; Wilson, BA; White, BA (2013). "A multi-omic systems-based approach reveals metabolic markers of bacterial vaginosis and insight into the disease". PLOS ONE. 8 (2): e56111. doi:10.1371/journal.pone.0056111. PMC 3566083  . PMID 23405259.

[5] Ludwig Brieger, "Weitere Untersuchungen über Ptomaine" [Further investigations into ptomaines] (Berlin, Germany: August Hirschwald, 1885), page 43. From page 43: Ich nenne dasselbe Putrescin, von putresco, faul werden, vermodern, verwesen. (I call this [compound] "putrescine", from [the Latin word] putresco, to become rotten, decay, rot.)

[6] Ludwig Brieger, "Weitere Untersuchungen über Ptomaine" [Further investigations into ptomaines] (Berlin, Germany: August Hirschwald, 1885), page 39.

[7] Brief biography of Ludwig Brieger (in German). Biography of Ludwig Brieger in English.

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