Isradipin

Isradipin adalah penghalang saluran kalsium dari kelas dihidropiridina. Obat ini biasanya diresepkan untuk mengobati tekanan darah tinggi guna mengurangi risiko strok dan serangan jantung. Obat ini dipatenkan pada tahun 1978 dan disetujui untuk penggunaan medis pada tahun 1989.

Isradipin

Nama sistematis (IUPAC)
3-Metil 5-propan-2-il 4-(2,1,3-benzoksadiazol-4-il)-2,6-dimetil-1,4-dihidropiridina-3,5-dikarboksilat
Data klinis
Nama dagang	DynaCirc
AHFS/Drugs.com	monograph
MedlinePlus	a693048
Kat. kehamilan	C
Status hukum	POM (UK) ℞-only (US)
Rute	Oral
Data farmakokinetik
Bioavailabilitas	15-24%
Ikatan protein	95%
Metabolisme	100% (hati)
Waktu paruh	8 jam
Ekskresi	70% (ginjal), 30% (feses)
Pengenal
Nomor CAS	75695-93-1 Y
Kode ATC	C08CA03
PubChem	CID 3784
DrugBank	DB00270
ChemSpider	3652 Y
UNII	YO1UK1S598 Y
KEGG	D00349 Y
ChEMBL	CHEMBL1648 Y
Data kimia
Rumus	C19H21N3O5
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 Y Key:HMJIYCCIJYRONP-UHFFFAOYSA-N Y

Bacaan lebih lanjut

• Hattori T, Wang P (2006). "Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts". Eur J Med Res. 11 (3): 93–6. PMID 16751108. 
• Ganz M, Mokabberi R, Sica D (2005). "Comparison of blood pressure control with amlodipine and controlled-release isradipine: an open-label, drug substitution study". The Journal of Clinical Hypertension. 7 (4 Suppl 1): 27–31. doi:10.1111/j.1524-6175.2005.04450.x . PMC 8109349  . PMID 15858400. 
• Johnson B, Roache J, Ait-Daoud N, Wallace C, Wells L, Dawes M, Wang Y (2005). "Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects". Int J Neuropsychopharmacol. 8 (2): 203–13. doi:10.1017/S1461145704005036 . PMID 15850499. 
• Fletcher H, Roberts G, Mullings A, Forrester T (1999). "An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia". J Obstet Gynaecol. 19 (3): 235–8. doi:10.1080/01443619964977. PMID 15512286. 
• Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ (2007). "'Rejuvenation' protects neurons in mouse models of Parkinson's disease". Nature. 447 (3): 1081–1086. Bibcode:2007Natur.447.1081C. doi:10.1038/nature05865. PMID 17558391. 

Pranala luar

• Templat:MedlinePlusDrugInfo
• Templat:DiseasesDB
• Drug offers hope for Parkinson's - BBC News, 11 June 2007.
• [1] - Commentary of Chan et al. publication
• [2] - ArsTechnica - Why neurons die in Parkinson's patients