Kaspofungin

Kaspofungin
Nama sistematis (IUPAC)
	(10R,12S)-N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-Aminoetil)amino]-20-[(1R)-3-amino-1-hidroksipropil]-23-[(1S,2S)-1,2-dihidroksi-2-(4-hidroksifenil)etil]-2,11,15-trihidroksi-6-[(1R)-1-hidroksietil]-5,8,14,19,22,25-heksaoksotetrakosahidro-1H-dipirolo[2,1-c:2',1'-l] [1,4,7,10,13,16]heksaazasiklohenikosin-9-il}-10,12-dimetiltetradekanamida
Data klinis
Nama dagang	Cancidas
AHFS/Drugs.com	monograph
MedlinePlus	a615001
Data lisensi	US Daily Med:pranala
Kat. kehamilan	B3(AU)
Status hukum	Harus dengan resep dokter (S4) (AU) ℞-only (US) ℞ Preskripsi saja
Rute	Intravena
Data farmakokinetik
Bioavailabilitas	100% (hanya untuk penggunaan intravena)
Ikatan protein	~97%
Metabolisme	Hati
Waktu paruh	9–11 jam
Ekskresi	Ginjal (41%), feses (35%)
Pengenal
Nomor CAS	162808-62-0
Kode ATC	J02AX04
PubChem	CID 16119814
DrugBank	DB00520
ChemSpider	17277006
UNII	F0XDI6ZL63
KEGG	D07626
ChEBI	CHEBI:474180
ChEMBL	CHEMBL499808
Sinonim	(4R,5S)-5-[(2-Aminoetil)amino]-N2-(10,12-dimetiltetradekanoil)-; 4-hidroksi-L-ornitil-L-treonil-trans-4-hidroksi-L-prolil-(S)-4-hidroksi-4-(p-hidroksifenil)-L-treonil-treo-3-hidroksi-L-ornitil-trans-3-hidroksi-L-prolina siklik (6→1)-peptida; :185 1-[(4R,5S)-5-[(2-Aminoetil)amino]-N2-(10,12-dimetil-1-oksotetradesil)-4-hidroksi-L-ornitina]-5-[(3R)-3-hidroksi-L-ornitina] pneumokandin B0
Data kimia
Rumus	C52H88N10O15
	InChI InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-/m0/s1 ; Key:JYIKNQVWKBUSNH-WVDDFWQHSA-N ;

Kaspofungin (INN)^[1]^[3] adalah obat antijamur lipopeptida yang dikembangkan oleh Merck & Co., Inc..^[4]

kaspofungin adalah penghambat pertama sintesis (1→3)-β-D-glukan jamur yang disetujui oleh Badan Pengawas Obat dan Makanan Amerika Serikat.^[5] Kaspofungin diberikan secara intravena.^[2] Obat ini tercantum dalam Daftar Obat Esensial Organisasi Kesehatan Dunia.^[6]

Efek samping

Farmakologi

Referensi

^ ^a ^b "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec.INN): List 42" (PDF). World Health Organization. 1999. Diakses tanggal 11 November 2016.
^ ^a ^b Kesalahan pengutipan: Tag <ref> tidak sah; tidak ditemukan teks untuk ref bernama Cancidas FDA label
^ European Medicines Agency's list of authorised medicines for human use (C) Diarsipkan 17 October 2007 di Wayback Machine.
^ "Patent Covering Caspofungin". Diakses tanggal 18 March 2015.
^ Deresinski SC, Stevens DA (June 2003). "Caspofungin". Clinical Infectious Diseases. 36 (11): 1445–57. doi:10.1086/375080  . PMID 12766841.
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090  . WHO/MHP/HPS/EML/2023.02.

[INN-1] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec.INN): List 42" (PDF). World Health Organization. 1999. Diakses tanggal 11 November 2016.

[Cancidas_FDA_label-2] Kesalahan pengutipan: Tag <ref> tidak sah; tidak ditemukan teks untuk ref bernama Cancidas FDA label

[3] European Medicines Agency's list of authorised medicines for human use (C) Diarsipkan 17 October 2007 di Wayback Machine.

[Fungicides,_antiprotozoa_agents,_microbiocides-4] "Patent Covering Caspofungin". Diakses tanggal 18 March 2015.

[Deresinski_SC_2003_1445–1457-5] Deresinski SC, Stevens DA (June 2003). "Caspofungin". Clinical Infectious Diseases. 36 (11): 1445–57. doi:10.1086/375080  . PMID 12766841.

[WHO23rd-6] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090  . WHO/MHP/HPS/EML/2023.02.

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