Nelfinavir

Nelfinavir
Nama sistematis (IUPAC)
	(3S,4aS,8aS)-N-tert-butil-2-[(2R,3R)-2-hidroksi-3-[(3-hidroksi-2-metilfenil)formamido]-4-(fenilsulfanil)butil]-dekahidroisokuinolina-3-karboksamida
Data klinis
Nama dagang	Viracept
AHFS/Drugs.com	monograph
MedlinePlus	a697034
Data lisensi	US Daily Med:pranala
Kat. kehamilan	?
Status hukum	℞-only (US)
Rute	Oral
Data farmakokinetik
Bioavailabilitas	Uncertain; increases when taking with food
Ikatan protein	>98%
Metabolisme	Liver by CYP including CYP3A4 and CYP2C19
Waktu paruh	3,5–5 jam
Ekskresi	feses (87%), urin (1–2%)
Pengenal
Nomor CAS	159989-64-7
Kode ATC	J05AE04
PubChem	CID 64143
DrugBank	DB00220
ChemSpider	57718
UNII	HO3OGH5D7I
KEGG	D08259
ChEBI	CHEBI:7496
ChEMBL	CHEMBL1159655
NIAID ChemDB	AIDSNO:028590
Sinonim	NFV
Data kimia
Rumus	C32H45N3O4S
SMILES	eMolecules & PubChem
	InChI InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1 ; Key:QAGYKUNXZHXKMR-HKWSIXNMSA-N ;
Data fisik
Titik lebur	349.94 °C (662 °F)

Nelfinavir adalah obat antiretroviral yang digunakan dalam pengobatan HIV/AIDS. Nelfinavir termasuk dalam golongan obat yang dikenal sebagai penghambat protease (PI) dan seperti PI lainnya, hampir selalu digunakan dalam kombinasi dengan obat antiretroviral lainnya.

Nelfinavir adalah penghambat protease HIV-1 human immunodeficiency virus yang tersedia secara hayati, digunakan secara oral (K_i = 2 nM), dan secara luas diresepkan dalam kombinasi dengan penghambat transkriptase balik HIV untuk pengobatan infeksi HIV.^[2]

Obat ini dipatenkan pada tahun 1992 dan disetujui untuk penggunaan medis pada tahun 1997.^[3]

^ "Viracept (nelfinavir mesylate) Tablets and Oral Powder, for Oral Use. Full Prescribing Information" (PDF). ViiV Healthcare Company. Research Triangle Park, NC 27709. Diakses tanggal 23 November 2015.
^ Zhang KE, Wu E, Patick AK, Kerr B, Zorbas M, Lankford A, et al. (April 2001). "Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities". Antimicrobial Agents and Chemotherapy. 45 (4): 1086–1093. doi:10.1128/AAC.45.4.1086-1093.2001. PMC 90428 . PMID 11257019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 510. ISBN 9783527607495.

[1] "Viracept (nelfinavir mesylate) Tablets and Oral Powder, for Oral Use. Full Prescribing Information" (PDF). ViiV Healthcare Company. Research Triangle Park, NC 27709. Diakses tanggal 23 November 2015.

[2] Zhang KE, Wu E, Patick AK, Kerr B, Zorbas M, Lankford A, et al. (April 2001). "Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities". Antimicrobial Agents and Chemotherapy. 45 (4): 1086–1093. doi:10.1128/AAC.45.4.1086-1093.2001. PMC 90428 . PMID 11257019.

[Fis2006-3] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 510. ISBN 9783527607495.

[1]

[2]

[3]



Nama sistematis (IUPAC)
(3S,4aS,8aS)-N-tert-butil-2-[(2R,3R)-2-hidroksi-3-[(3-hidroksi-2-metilfenil)formamido]-4-(fenilsulfanil)butil]-dekahidroisokuinolina-3-karboksamida
Data klinis
Nama dagang	Viracept
AHFS/Drugs.com	monograph
MedlinePlus	a697034
Data lisensi	US Daily Med:pranala
Kat. kehamilan	?
Status hukum	℞-only (US)
Rute	Oral
Data farmakokinetik
Bioavailabilitas	Uncertain; increases when taking with food^[1]
Ikatan protein	>98%
Metabolisme	Liver by CYP including CYP3A4 and CYP2C19
Waktu paruh	3,5–5 jam
Ekskresi	feses (87%), urin (1–2%)
Pengenal
Nomor CAS	159989-64-7^Y
Kode ATC	J05AE04
PubChem	CID 64143
DrugBank	DB00220
ChemSpider	57718^Y
UNII	HO3OGH5D7I^Y
KEGG	D08259^Y
ChEBI	CHEBI:7496^N
ChEMBL	CHEMBL1159655^N
NIAID ChemDB	AIDSNO:028590
Sinonim	NFV
Data kimia
Rumus	C₃₂H₄₅N₃O₄S
SMILES	eMolecules & PubChem
InChI InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1^Y Key:QAGYKUNXZHXKMR-HKWSIXNMSA-N^Y
Data fisik
Titik lebur	349.94 °C (662 °F)