Amiodaron

Amiodaron
Nama sistematis (IUPAC)
	(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine
Data klinis
Nama dagang	Cordarone, Nexterone, Pacerone, others
AHFS/Drugs.com	monograph
MedlinePlus	a687009
Data lisensi	US Daily Med:pranala
Kat. kehamilan	C(AU)
Status hukum	Harus dengan resep dokter (S4) (AU) ℞-only (CA) ℞-only (US)
Rute	By mouth, intravenous, intraosseous
Data farmakokinetik
Bioavailabilitas	20–55%
Ikatan protein	96%
Metabolisme	Liver
Waktu paruh	58 d (range 15–142 d)
Ekskresi	Primarily liver and bile
Pengenal
Nomor CAS	1951-25-3
Kode ATC	C01BD01
PubChem	CID 2157
Ligan IUPHAR	2566
DrugBank	DB01118
ChemSpider	2072
UNII	N3RQ532IUT
KEGG	D02910
ChEBI	CHEBI:2663
ChEMBL	CHEMBL633
Data kimia
Rumus	C25H29I2NO3
	InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3 ; Key:IYIKLHRQXLHMJQ-UHFFFAOYSA-N ;

Amiodaron adalah obat antiaritmia, FDA Amerika Serikat (Food and Drug Administration), telah memberi label amiodaron untuk pengobatan aritmia ventrikel yang mengancam jiwa, obat ini umumnya digunakan di luar label untuk mengobati takiaritmia supraventrikular seperti fibrilasi atrium serta untuk pencegahan takiaritmia ventrikel (VT) pada risiko tinggi pasien.^[1]^[2]^[3]

Referensi sunting

^ Voulgareli, Ilektra; Chronaiou, Alexandra; Tsoukalas, Dionisios; Tsoukalas, George (2018-12). "A rare case of lipoid pneumonia attributed to amiodarone". Pneumonia. 10 (1). doi:10.1186/s41479-018-0056-3. ISSN 2200-6133.
^ Soar, Jasmeet; Perkins, Gavin D.; Maconochie, Ian; Böttiger, Bernd W.; Deakin, Charles D.; Sandroni, Claudio; Olasveengen, Theresa M.; Wyllie, Jonathan; Greif, Robert (2019-01). "European Resuscitation Council Guidelines for Resuscitation: 2018 Update – Antiarrhythmic drugs for cardiac arrest". Resuscitation. 134: 99–103. doi:10.1016/j.resuscitation.2018.11.018. ISSN 0300-9572.
^ Serhan Özcan, Kazım; Zengin, Ahmet; Tatlısu, Adem; Aruğarslan, Emre; Nurkalem, Zekeriya (2014-02). "Anaphylactic shock associated with intravenous amiodarone". Journal of Cardiology Cases. 9 (2): 61–62. doi:10.1016/j.jccase.2013.10.001. ISSN 1878-5409.

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[1] Voulgareli, Ilektra; Chronaiou, Alexandra; Tsoukalas, Dionisios; Tsoukalas, George (2018-12). "A rare case of lipoid pneumonia attributed to amiodarone". Pneumonia. 10 (1). doi:10.1186/s41479-018-0056-3. ISSN 2200-6133.

[2] Soar, Jasmeet; Perkins, Gavin D.; Maconochie, Ian; Böttiger, Bernd W.; Deakin, Charles D.; Sandroni, Claudio; Olasveengen, Theresa M.; Wyllie, Jonathan; Greif, Robert (2019-01). "European Resuscitation Council Guidelines for Resuscitation: 2018 Update – Antiarrhythmic drugs for cardiac arrest". Resuscitation. 134: 99–103. doi:10.1016/j.resuscitation.2018.11.018. ISSN 0300-9572.

[3] Serhan Özcan, Kazım; Zengin, Ahmet; Tatlısu, Adem; Aruğarslan, Emre; Nurkalem, Zekeriya (2014-02). "Anaphylactic shock associated with intravenous amiodarone". Journal of Cardiology Cases. 9 (2): 61–62. doi:10.1016/j.jccase.2013.10.001. ISSN 1878-5409.

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