Etilmorfin

Etilmorfin
Nama sistematis (IUPAC)
	7,8-didehidro-4,5-α-epoksi- 3-etoksi-17-metilmorfinan-6-α-ol
Data klinis
Nama dagang	Cosylan, Diolan, Dionina, Diosan, Solvipect, Trachyl
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	Schedule I (CA) ? (UK) Schedule II (US)
Pengenal
Nomor CAS	76-58-4
Kode ATC	R05DA01 S01XA06
PubChem	CID 5359271
DrugBank	DB01466
ChemSpider	4514250
UNII	RWO67D87EU
KEGG	D07929
Data kimia
Rumus	C19H23NO3
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1 ; Key:OGDVEMNWJVYAJL-LEPYJNQMSA-N ;

Etilmorfin (juga dikenal sebagai kodetilin, dionin, dan etil morfin) adalah analgesik dan antitusif opioid.^[1]^[2]^[3]^[4]^[5]^[6]

Efek samping

Efek sampingnya mirip dengan opioid lain dan meliputi rasa kantuk, sembelit, vertigo, mual, muntah, dan depresi pernapasan. Kontraindikasi meliputi asma, insufisiensi pernapasan, dan usia di bawah 8 tahun. Etilmorfin dapat memengaruhi kemampuan pengguna untuk mengemudi dan mengoperasikan mesin berat, dan dapat menyebabkan ketergantungan atau kecanduan zat kimia pada dosis tinggi.^[7]

Dalam budaya masyarakat

Etilmorfin pertama kali dipasarkan di Prancis pada tahun 1953 oleh Houde, dan di Norwegia dan Spanyol pada tahun 1960. Obat ini tidak tersedia di Amerika Serikat, karena obat ini merupakan zat yang dikendalikan Schedule II.^[7]^[8]

Referensi

^ Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J (April 1997). "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology. 80 (4): 171–81. doi:10.1111/j.1600-0773.1997.tb00392.x  . PMID 9140136.
^ Jonasson B, Jonasson U, Holmgren P, Saldeen T (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. PMID 10460420.
^ Popa C, Beck O, Brodin K (March–April 1998). "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology. 22 (2): 142–7. doi:10.1093/jat/22.2.142  . PMID 9547411.
^ Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.
^ Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology. 39 (6): 611–20. doi:10.1111/j.1365-2125.1995.tb05720.x. PMC 1365072  . PMID 7654478.
^ Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. PMC 1364985  . PMID 7756104.
^ ^a ^b Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. hlm. 79. ISBN 0-8103-7177-4.
^ PubChem. "Ethylmorphine". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2023-09-08.

Artikel bertopik farmasi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J (April 1997). "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology. 80 (4): 171–81. doi:10.1111/j.1600-0773.1997.tb00392.x  . PMID 9140136.

[2] Jonasson B, Jonasson U, Holmgren P, Saldeen T (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. PMID 10460420.

[3] Popa C, Beck O, Brodin K (March–April 1998). "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology. 22 (2): 142–7. doi:10.1093/jat/22.2.142  . PMID 9547411.

[4] Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.

[5] Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology. 39 (6): 611–20. doi:10.1111/j.1365-2125.1995.tb05720.x. PMC 1365072  . PMID 7654478.

[6] Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. PMC 1364985  . PMID 7756104.

[DAA-7] Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. hlm. 79. ISBN 0-8103-7177-4.

[8] PubChem. "Ethylmorphine". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2023-09-08.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]