Karbosistein

Karbosistein
Nama
	Nama IUPAC (R)-2-Amino-3-(karboksimetilsulfanil)asam propanoat
	Nama lain S-Karboksimetil-L-sistein; Aktitiol, Lisomucil, Musiklar, Mukodina, Mukoleks, Rinatiol, Transbronkin
Penanda
Nomor CAS	638-23-3 ; 25390-17-4 (DL) ;
Model 3D (JSmol)	Gambar interaktif; Gambar interaktif;
3DMet	{{{3DMet}}}
ChEBI	CHEBI:16163 ;
ChEMBL	ChEMBL396416 ;
ChemSpider	168055 ;
DrugBank	DB04339 ;
Nomor EC
KEGG	D06393 ; D00175;
PubChem CID	193653;
Nomor RTECS	{{{value}}}
UNII	740J2QX53R ; 4252LRM78Q (DL) ;
CompTox Dashboard (EPA)	DTXSID30110060 ;
	InChI InChI=1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 Key: GBFLZEXEOZUWRN-VKHMYHEASA-N ; InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) Key: GBFLZEXEOZUWRN-UHFFFAOYAN; InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 Key: GBFLZEXEOZUWRN-VKHMYHEABX;
	SMILES O=C(O)C(N)CSCC(=O)O; O=C(O)[C@@H](N)CSCC(=O)O;
Sifat
Rumus kimia	C5H9NO4S
Massa molar	179,19 g·mol−1
Penampilan	Padatan tak berwarna
Titik lebur	204 hingga 207 °C (399 hingga 405 °F; 477 hingga 480 K)
Farmakologi
Kode ATC	R05CB03
	Kecuali dinyatakan lain, data di atas berlaku pada suhu dan tekanan standar (25 °C [77 °F], 100 kPa).
	verifikasi (apa ini ?)
	Referensi

Karbosistein adalah mukolitik yang mengurangi viskositas dahak sehingga dapat digunakan untuk membantu meredakan gejala penyakit paru obstruktif kronik (PPOK) dan bronkientasis dengan memungkinkan penderitanya mengeluarkan dahak dengan lebih mudah.^[2]^[3] Karbosistein tidak boleh digunakan bersama antitusif (obat penekan batuk) atau obat yang mengeringkan sekresi bronkial.

Obat ini pertama kali dideskripsikan pada tahun 1951 dan mulai digunakan dalam dunia medis pada tahun 1960.^[4] Karbosistein diproduksi melalui alkilasi sisteina dengan asam kloroasetat.^[5]

Referensi

^ Carbocisteine. drugbank.ca
^ Zheng JP, Kang J, Huang SG, Chen P, Yao WZ, Yang L, Bai CX, Wang CZ, Wang C, Chen BY, Shi Y, Liu CT, Chen P, Li Q, Wang ZS, Huang YJ, Luo ZY, Chen FP, Yuan JZ, Yuan BT, Qian HP, Zhi RC, Zhong NS (2008). "Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): A randomised placebo-controlled study". Lancet. 371 (9629): 2013–2018. doi:10.1016/S0140-6736(08)60869-7. PMID 18555912.
^ Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K, Tomita N, Yoshida M, Sasaki H (2006). "Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease". Journal of the American Geriatrics Society. 54 (2): 378–380. doi:10.1111/j.1532-5415.2005.00592_9.x  . PMID 16460403.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. hlm. 544. ISBN 9783527607495.
^ Karlheinz Drauz; Ian Grayson; Axel Kleemann; Hans‐Peter Krimmer; Wolfgang Leuchtenberger; Christoph Weckbecker (2005), "Amino Acids", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a02_057.pub2

[1] Carbocisteine. drugbank.ca

[2] Zheng JP, Kang J, Huang SG, Chen P, Yao WZ, Yang L, Bai CX, Wang CZ, Wang C, Chen BY, Shi Y, Liu CT, Chen P, Li Q, Wang ZS, Huang YJ, Luo ZY, Chen FP, Yuan JZ, Yuan BT, Qian HP, Zhi RC, Zhong NS (2008). "Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): A randomised placebo-controlled study". Lancet. 371 (9629): 2013–2018. doi:10.1016/S0140-6736(08)60869-7. PMID 18555912.

[3] Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K, Tomita N, Yoshida M, Sasaki H (2006). "Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease". Journal of the American Geriatrics Society. 54 (2): 378–380. doi:10.1111/j.1532-5415.2005.00592_9.x  . PMID 16460403.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. hlm. 544. ISBN 9783527607495.

[5] Karlheinz Drauz; Ian Grayson; Axel Kleemann; Hans‐Peter Krimmer; Wolfgang Leuchtenberger; Christoph Weckbecker (2005), "Amino Acids", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a02_057.pub2

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