Metdilazin

senyawa kimia

Metdilazin adalah antihistamin generasi pertama dengan sifat antikolinergik dari kelas fenotiazin.

Metdilazin
Nama sistematis (IUPAC)
10-[(1-metilpirolidin-3-il) metil]- 10H-fenotiazina
Data klinis
AHFS/Drugs.com monograph
Kat. kehamilan ?
Status hukum ?
Pengenal
Nomor CAS 1982-37-2 YaY
Kode ATC R06AD04
PubChem CID 14677
Ligan IUPHAR 7231
DrugBank DB00902
ChemSpider 14009 YaY
UNII 4Q13LY9Z8X YaY
KEGG D04979 YaY
ChEBI CHEBI:6823
ChEMBL CHEMBL1200959 N
Data kimia
Rumus C18H20N2S 
SMILES eMolecules & PubChem
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 YaY
    Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N YaY

Sintesis

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Sintesis metdilazin:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; Templat:US Patent (1960).

Referensi

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  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).

Bacaan lebih lanjut

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  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002 . PMID 15782943. 
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83 . PMID 9700532. 
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.