Dimetinden

Dimetinden
Nama sistematis (IUPAC)
	N,N-Dimetil-2-[3-(1-piridin-2-iletil)-1H-inden-2-il]etan-1-amina
Data klinis
Nama dagang	Fenistil, dll
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	Harus dengan resep dokter (S4) (AU) GSL (UK)
Rute	Oral, topikal
Pengenal
Nomor CAS	5636-83-9 3614-69-5
Kode ATC	D04AA13 R06AB03
PubChem	CID 21855
DrugBank	DB08801
ChemSpider	20541
UNII	661FH77Z3P
KEGG	D07853
ChEMBL	CHEMBL22108
Data kimia
Rumus	C20H24N2
SMILES	eMolecules & PubChem
	InChI InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 ; Key:MVMQESMQSYOVGV-UHFFFAOYSA-N ;

Dimetinden adalah suatu antihistamin dan antikolinergik. Obat ini merupakan antagonis H1 selektif generasi pertama.^[1]^[2] Dimetinden merupakan antagonis H1 generasi pertama yang tidak umum karena hanya sedikit melewati sawar darah otak.^[3]

Dimetinden juga merupakan antagonis reseptor M2.^[4]

Obat ini dipatenkan pada tahun 1958 dan mulai digunakan dalam dunia medis pada tahun 1960.^[5]

^ Fromer LM, Ortiz GR, Dowdee AM (September 2008). "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey". The World Allergy Organization Journal. 1 (9): 156–159. doi:10.1186/1939-4551-1-9-145 . PMC 3651039 . PMID 23282579.
^ "Dimetindene". Drugs.com.
^ Noguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.
^ Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N (April 2010). "Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats". Urology. 75 (4): 862–867. doi:10.1016/j.urology.2009.12.013. PMC 2871158 . PMID 20156651.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 547. ISBN 9783527607495.

[1] Fromer LM, Ortiz GR, Dowdee AM (September 2008). "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey". The World Allergy Organization Journal. 1 (9): 156–159. doi:10.1186/1939-4551-1-9-145 . PMC 3651039 . PMID 23282579.

[2] "Dimetindene". Drugs.com.

[3] Noguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.

[4] Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N (April 2010). "Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats". Urology. 75 (4): 862–867. doi:10.1016/j.urology.2009.12.013. PMC 2871158 . PMID 20156651.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 547. ISBN 9783527607495.

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