Meklizin

Meklizin
Nama sistematis (IUPAC)
	(RS)-1-[(4-klorofenil)(fenil)metil]-4-(3-metilbenzil)piperazina
Data klinis
Nama dagang	Bonine, Antivert, dll
AHFS/Drugs.com	monograph
MedlinePlus	a682548
Data lisensi	US Daily Med:pranala
Kat. kehamilan	?
Status hukum	Harus dengan resep dokter (S4) (AU) OTC (CA) OTC (US)
Rute	oral, sublingual, di rongga bukal
Data farmakokinetik
Bioavailabilitas	22 - 32%
Metabolisme	Hati (CYP2D6)
Waktu paruh	5-6 jam
Pengenal
Nomor CAS	569-65-3
Kode ATC	R06AE05
PubChem	CID 4034
Ligan IUPHAR	2757
DrugBank	DB00737
ChemSpider	3894
UNII	3L5TQ84570
KEGG	D08163
ChEMBL	CHEMBL1623
Sinonim	Meclozine
Data kimia
Rumus	C25H27ClN2
	InChI InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3 ; Key:OCJYIGYOJCODJL-UHFFFAOYSA-N ;
Data fisik
Titik didih	230 °C (446 °F)

Meklizin adalah antihistamin yang digunakan untuk mengobati mabuk perjalanan dan pusing (vertigo). Meklizin digunakan dengan cara diminum. Efeknya biasanya mulai terasa dalam waktu satu jam dan bertahan hingga satu hari.^[3]

Efek samping yang umum termasuk rasa kantuk dan mulut kering. Efek samping yang serius mungkin termasuk reaksi alergi.^[3] Penggunaan selama kehamilan tampaknya aman, tetapi belum diteliti dengan baik; penggunaan selama menyusui tidak jelas keamanannya.^[4] Meklizin diyakini bekerja sebagian melalui mekanisme antikolinergik dan antihistamin.^[3]

Meklizin dipatenkan pada tahun 1951 dan mulai digunakan dalam dunia medis pada tahun 1953.^[5] Meklizin tersedia sebagai obat generik dan sering kali dijual bebas.^[3]^[6]

^ Sun J, Liu J, Zhang J, Xia H (June 2021). "Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability improvement". Journal of Drug Delivery Science and Technology. 63: 102432. doi:10.1016/j.jddst.2021.102432.
^ Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, Chow MS (September 2012). "Meclizine metabolism and pharmacokinetics: formulation on its absorption". Journal of Clinical Pharmacology. 52 (9): 1343–1349. doi:10.1177/0091270011414575. PMID 21903894.
^ ^a ^b ^c ^d "Meclizine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Diakses tanggal 22 March 2019.
^ "Meclizine Use During Pregnancy". Drugs.com. Diakses tanggal 3 March 2019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. hlm. 547. ISBN 9783527607495.
^ Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (2015). Advanced Therapies in Pediatric Endocrinology and Diabetology: Workshop, Rome, October 2014. Karger Medical and Scientific Publishers. hlm. 101. ISBN 9783318056372.

[bioavail-1] Sun J, Liu J, Zhang J, Xia H (June 2021). "Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability improvement". Journal of Drug Delivery Science and Technology. 63: 102432. doi:10.1016/j.jddst.2021.102432.

[pharmacokinetics-2] Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, Chow MS (September 2012). "Meclizine metabolism and pharmacokinetics: formulation on its absorption". Journal of Clinical Pharmacology. 52 (9): 1343–1349. doi:10.1177/0091270011414575. PMID 21903894.

[AHFS2019-3] "Meclizine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Diakses tanggal 22 March 2019.

[Preg2019-4] "Meclizine Use During Pregnancy". Drugs.com. Diakses tanggal 3 March 2019.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. hlm. 547. ISBN 9783527607495.

[6] Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (2015). Advanced Therapies in Pediatric Endocrinology and Diabetology: Workshop, Rome, October 2014. Karger Medical and Scientific Publishers. hlm. 101. ISBN 9783318056372.

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